tetrabenzyl methylenediphosphonate

Base Information

• Chemical Name: tetrabenzyl methylenediphosphonate
• CAS No.: 133918-47-5
• Molecular Formula: C₂₉H₃₀O₆P₂
• Molecular Weight: 536.501
• Mol file: 133918-47-5.mol

Synonyms:tetrabenzyl methylenediphosphonate

Chemical Property of tetrabenzyl methylenediphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetrabenzyl methylenediphosphonate

There total 10 articles about tetrabenzyl methylenediphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tribenzyl phosphite (15205-57-9) + dibenzyl (chloromethyl)phosphonate (166049-87-2) → tetrabenzyl methylenediphosphonate (133918-47-5)

Guidance literature:

at 140 ℃; for 8h; under 6 - 10 Torr;

DOI:10.1002/hlca.19950780314

Reference yield: 77.0%

Methylenediphosphonic acid (1984-15-2) + tris(benzyloxy)methane (29134-54-1) → tetrabenzyl methylenediphosphonate (133918-47-5)

Guidance literature:

at 150 ℃; for 2h;

DOI:10.1016/S0968-0896(99)00045-0

Reference yield: 76.0%

P,P'-methanediyl-bis-phosphonic acid tetrachloride (1499-29-2) + benzyl alcohol (100-51-6,185532-71-2) → tetrabenzyl methylenediphosphonate (133918-47-5)

Guidance literature:

With pyridine; In toluene; at 0 - 20 ℃;

DOI:10.1081/SCC-120002004

upstream raw materials:

tribenzyl phosphite

dibenzyl (chloromethyl)phosphonate

Methylenediphosphonic acid

tris(benzyloxy)methane

Downstream raw materials:

tetrabenzyl 2-(4-carbomethoxyphenyl)ethane-1,1-diphosphonate

Tetrabenzyl 1-chloro-1-oxo-propylene-3,3-bisphosphonate

C₂₆H₂₄N₃O₅P

C₁₉H₂₁O₃P

Refernces

• 1、 Mons, Stéphane,Klein, Emmanuel,Mioskowski, Charles,Lebeau, Luc. "Selenophosphonates as building blocks for the preparation of bis-methylene analogs of triphosphates". . p. 5439 - 5442. Retrieved 2001.
• 2、 -. "COMPOSITIONS AND METHODS OF MODULATING THE IMMUNE RESPONSE BY ACTIVATING ALPHA PROTEIN KINASE 1". Paragraph 239. . Retrieved 2019/05/15.
• 3、 -. "PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS". Page/Page column 77. . Retrieved 2011/11/06.