3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE

Base Information

• Chemical Name: 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE
• CAS No.: 175277-50-6
• Molecular Formula: C7H3ClF3NO
• Molecular Weight: 209.555
• Hs Code.: 2933399990
• Mol file: 175277-50-6.mol

Synonyms:3-Chloro-5-trifluoromethylpyridine-2-carboxaldehyde;

Chemical Property of 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 0.26mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 204.689 °C at 760 mmHg
• PKA: -1.30±0.10(Predicted)
• Flash Point: 77.594 °C
• PSA: 29.96000
• Density: 1.499 g/cm³
• LogP: 2.56630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-5-(trifluoromethyl)picolinaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxaldehyde, a specific chemical compound, serves varied purposes across distinct fields. In the pharmaceutical sector, it acts as a valuable intermediate in the synthesis of pharmaceutical compounds, contributing to the creation of molecules with potential therapeutic applications. In organic chemistry, this compound serves as a versatile building block, enabling the construction of complex molecular structures and supporting advancements in chemical research. Additionally, in the field of agrochemicals, it might play a role in the formulation of pesticides, aiding in pest management and enhancing crop yield. Its multifaceted applications in pharmaceuticals, chemistry, and agriculture underscore its significance in driving innovation, scientific exploration, and practical solutions in these vital domains.

Technology Process of 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE

There total 3 articles about 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanol (1033463-31-8) → 3-chloro-5-(trifluoromethyl)picolinaldehyde (175277-50-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 23 ℃; for 3h;

Reference yield:

3-chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester (128073-16-5) → 3-chloro-5-(trifluoromethyl)picolinaldehyde (175277-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 4 h / 0 - 23 °C

2: Dess-Martin periodane / dichloromethane / 3 h / 0 - 23 °C

With methanol; sodium tetrahydroborate; Dess-Martin periodane; In dichloromethane;

Reference yield:

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-5-(trifluoromethyl)picolinaldehyde (175277-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate / 6 h / 90 °C / 11377.6 Torr / Autoclave

2: methanol; sodium tetrahydroborate / 4 h / 0 - 23 °C

3: Dess-Martin periodane / dichloromethane / 3 h / 0 - 23 °C

With methanol; sodium tetrahydroborate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate; palladium diacetate; Dess-Martin periodane; In dichloromethane;

upstream raw materials:

3-chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester

(3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanol

2,3-dichloro-5-trifluoromethylpyridine

Downstream raw materials:

3-chloro-2-cyano-5-(trifluoromethyl)pyridine

3-chloro-5-(trifluoromethyl)picolinaldehydeoxime

3-[3-chloro-5-(trifluoromethyl)-pyridin-2-yl]-1-(2-nitrophenyl)-2-propen-1-one

3-chloro-5-(trifluoromethyl)-2-pyridinecarbaldehyde 2-(2-nitrophenyl)hydrazone

Refernces