1-(4-Methoxyphenyl)but-3-en-1-ol

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)but-3-en-1-ol
• CAS No.: 24165-60-4
• Molecular Formula: C11H14 O2
• Molecular Weight: 178.231
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID50390761
• Nikkaji Number: J328.395J
• Mol file: 24165-60-4.mol

Synonyms:1-(4-methoxyphenyl)but-3-en-1-ol;24165-60-4;1-(4-Methoxyphenyl)-3-buten-1-ol;4-(4-METHYOXY)PHENYL-1-BUTEN-4-OL;4-(4-Methoxyphenyl)-1-buten-4-ol;SCHEMBL334865;DTXSID50390761;4-Methoxy-alpha-allylbenzyl alcohol;AKOS010638301;SB84964;WS-00350;CS-0266436;EN300-375838;W18879;4-(4-METHYOXY)PHENYL-1-BUTEN-4-OL97;4-(4-METHYOXY)PHENYL-1-BUTEN-4-OL 97;J-015374;J-513557

Chemical Property of 1-(4-Methoxyphenyl)but-3-en-1-ol

Chemical Property:

• Vapor Pressure: 0.000746mmHg at 25°C
• Refractive Index: n20/D >1.5370(lit.)
• Boiling Point: 279 °C(lit.)
• PKA: 14.29±0.20(Predicted)
• Flash Point: >230 °F
• PSA: 29.46000
• Density: 1.047 g/mL at 25 °C(lit.)
• LogP: 2.30470
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 178.099379685
• Heavy Atom Count: 13
• Complexity: 148

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Methoxyphenyl)but-3-en-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CC=C)O

Technology Process of 1-(4-Methoxyphenyl)but-3-en-1-ol

There total 86 articles about 1-(4-Methoxyphenyl)but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + allyl bromide (106-95-6) → 1-(4-methoxyphenyl)but-3-en-1-ol (24165-60-4)

Guidance literature:

With tin(ll) chloride; zinc; In water; for 2h;

DOI:10.1016/j.tetlet.2004.05.070

Reference yield: 99.0%

tetraallyl tin (7393-43-3) + 4-methoxy-benzaldehyde (123-11-5) → 1-(4-methoxyphenyl)but-3-en-1-ol (24165-60-4)

Guidance literature:

With silica gel; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2003.09.181

Reference yield: 98.0%

4-methoxy-benzaldehyde (123-11-5) + potassium trifluoro(prop-1-en-2-yl)borate → 1-(4-methoxyphenyl)but-3-en-1-ol (24165-60-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In dichloromethane; water; at 20 ℃; for 0.25h;

DOI:10.1021/ol026619i

upstream raw materials:

allylmagnesium bromide

4-methoxy-benzaldehyde

trimethyl(allyl)stannane

allyl bromide

Downstream raw materials:

3-(p-methoxyphenyl)-1,5-hexadien-3-ol

1-(4-methoxyphenyl)but-3-en-1-one

1-acetoxy-1-(4'-methoxyphenyl)but-3-ene

(S)-1-(4-methoxyphenyl)but-3-en-1-ol

Refernces

• 1、 Tan, Xiang-Hui,Shen, Bo,Beng, Wei,Zhao, Hui,Liu, Lei,Guo, Qing-Xiang. "Novel carbonyl allylation mediated by SnCl2/TiCl3 in water". . p. 1833 - 1835. Retrieved 2003.
• 2、 Wada, Makoto,Fukuma, Tomohiro,Morioka, Mika,Takahashi, Toshikazu,Miyoshi, Norikazu. "A novel aqueous Barbier-Grignard-type allylation of aldehydes in a Mg/BiCl3 bimetal system". . p. 8045 - 8048. Retrieved 1997.
• 3、 Naruta,Y. et al.. "-". . p. 919 - 922. Retrieved 1979.
• 4、 Mondal, Bibhas,Adhikari, Utpal,Hajra, Partha Pratim,Roy, Ujjal Kanti. "Allylation and propargylation of aldehydes mediated byin situgenerated zinc from the redox couple of Al and ZnCl2in 2N HCl". . p. 7163 - 7173. Retrieved 2021/05/03.
• 5、 He, Xiaoxue,Qian, Lijie,Dai, Yuyu,Yan, Xinhuan,Li, Xiaoqing,Xu, Xiangsheng. "Copper-catalyzed radical oxyallylation of olefins for the construction of alkene-containing isoxazolines". supporting information. . Retrieved 2021/05/31.