Cyclobutanecarboxamide, N,N-dimethyl-3-methylene- (6CI)

Base Information

• Chemical Name: Cyclobutanecarboxamide, N,N-dimethyl-3-methylene- (6CI)
• CAS No.: 98425-72-0
• Molecular Formula: C8H13 N O
• Molecular Weight: 139.197
• Mol file: 98425-72-0.mol

Synonyms:Cyclobutanecarboxamide, N,N-dimethyl-3-methylene- (6CI)

Chemical Property of Cyclobutanecarboxamide, N,N-dimethyl-3-methylene- (6CI)

Chemical Property:

• Boiling Point: 67 °C (1 mmHg)
• PSA: 20.31000
• LogP: 1.04080

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxamide, N,N-dimethyl-3-methylene- (6CI)

There total 1 articles about Cyclobutanecarboxamide, N,N-dimethyl-3-methylene- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylenecyclobutanecarbonitrile (15760-35-7) → 3-methylene-cyclobutanecarboxylic acid dimethylamide (98425-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic KOH

2: chlorocarbonic acid ethyl ester; triethylamine; CHCl₃

With potassium hydroxide; chloroform; chloroformic acid ethyl ester; triethylamine;

DOI:10.1021/ja01553a049

Reference yield:

3-methylene-cyclobutanecarboxylic acid dimethylamide (98425-72-0) → 3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide (100050-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaIO₄; OsO₄

2: orthoformic acid triethyl ester; HCl

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

Reference yield:

3-methylene-cyclobutanecarboxylic acid dimethylamide (98425-72-0) → 3-dimethylaminomethyl-cyclobutanon-diethylacetal (100535-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaIO₄; OsO₄

2: orthoformic acid triethyl ester; HCl

3: LiAlH₄; diethyl ether

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; diethyl ether; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

upstream raw materials:

3-methylenecyclobutanecarbonitrile

Downstream raw materials:

N,N-dimethyl-3-oxocyclobutane-1-carboxamide

3-dimethylaminomethyl-cyclobutanon-diethylacetal

3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide