Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI)

Base Information

• Chemical Name: Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI)
• CAS No.: 100050-26-8
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• Mol file: 100050-26-8.mol

Synonyms:Cyclobutanecarboxamide,N,N-dimethyl-3-oxo-, diethyl acetal (6CI)

Chemical Property of Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI)

Chemical Property:

• PSA: 38.77000
• LogP: 1.25390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI)

There total 4 articles about Cyclobutanecarboxamide, N,N-dimethyl-3-oxo-, diethyl acetal (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxocyclobutanecarboxylic acid (23761-23-1) → 3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide (100050-26-8)

Guidance literature:

Multi-step reaction with 2 steps

2: orthoformic acid triethyl ester; HCl

With hydrogenchloride; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

Reference yield:

3-methylenecyclobutane-1-carboxylic acid (15760-36-8) → 3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide (100050-26-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaIO₄; OsO₄

3: orthoformic acid triethyl ester; HCl

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

Reference yield:

3-methylene-cyclobutanecarboxylic acid dimethylamide (98425-72-0) → 3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide (100050-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaIO₄; OsO₄

2: orthoformic acid triethyl ester; HCl

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

upstream raw materials:

ethanol

N,N-dimethyl-3-oxocyclobutane-1-carboxamide

3-oxocyclobutanecarboxylic acid

3-methylenecyclobutane-1-carboxylic acid

Downstream raw materials:

3-dimethylaminomethyl-cyclobutanon-diethylacetal