Cyclobutanone, 3-(dimethylaminomethyl)-, diethyl acetal (6CI)

Base Information

• Chemical Name: Cyclobutanone, 3-(dimethylaminomethyl)-, diethyl acetal (6CI)
• CAS No.: 100535-42-0
• Molecular Formula: C₁₁H₂₃NO₂
• Molecular Weight: 201.309
• Mol file: 100535-42-0.mol

Synonyms:Cyclobutanone,3-(dimethylaminomethyl)-, diethyl acetal (6CI)

Chemical Property of Cyclobutanone, 3-(dimethylaminomethyl)-, diethyl acetal (6CI)

Chemical Property:

• Boiling Point: 53 - 54 °C (1 mmHg)
• PSA: 21.70000
• LogP: 1.72730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanone, 3-(dimethylaminomethyl)-, diethyl acetal (6CI)

There total 5 articles about Cyclobutanone, 3-(dimethylaminomethyl)-, diethyl acetal (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide (100050-26-8) → 3-dimethylaminomethyl-cyclobutanon-diethylacetal (100535-42-0)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01554a064

Reference yield:

3-oxocyclobutanecarboxylic acid (23761-23-1) → 3-dimethylaminomethyl-cyclobutanon-diethylacetal (100535-42-0)

Guidance literature:

Multi-step reaction with 3 steps

2: orthoformic acid triethyl ester; HCl

3: LiAlH₄; diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; diethyl ether; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

Reference yield:

3-methylenecyclobutane-1-carboxylic acid (15760-36-8) → 3-dimethylaminomethyl-cyclobutanon-diethylacetal (100535-42-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NaIO₄; OsO₄

3: orthoformic acid triethyl ester; HCl

4: LiAlH₄; diethyl ether

With hydrogenchloride; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; diethyl ether; orthoformic acid triethyl ester;

DOI:10.1021/ja01554a064

upstream raw materials:

3,3-diethoxy-cyclobutanecarboxylic acid dimethylamide

3-oxocyclobutanecarboxylic acid

3-methylenecyclobutane-1-carboxylic acid

3-methylene-cyclobutanecarboxylic acid dimethylamide