Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-

Base Information

• Chemical Name: Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-
• CAS No.: 898562-94-2
• Molecular Formula: C25H20 N4 O
• Molecular Weight: 392.46
• Hs Code.: 2933990090
• Mol file: 898562-94-2.mol

Synonyms:2-[(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl]quinoline;MP 10

Chemical Property of Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.661
• Boiling Point: 568.569ºC at 760 mmHg
• PKA: 4.32±0.10(Predicted)
• Flash Point: 297.66ºC
• PSA: 52.83000
• Density: 1.216g/cm3
• LogP: 5.27630

Purity/Quality:

98% ^*data from raw suppliers

PF-2545920(MP-10) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-

There total 11 articles about Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-((4-(4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline (871507-11-8) + methylhydrazine (60-34-4) → 2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline (898562-94-2)

Guidance literature:

With sulfuric acid; In ethanol; at 20 ℃; for 1h;

Reference yield: 56.0%

3-(dimethylamino)-2-(pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)prop-2-en-1-one (871507-16-3) + methylhydrazine (60-34-4) → 2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline (898562-94-2) + 2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline (898562-93-1)

Guidance literature:

With sulfuric acid; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm900521k

Reference yield: 51.0%

2-((4-(4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline (871507-11-8) + methylhydrazine (60-34-4) → 2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline (898562-94-2) + 2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline (898562-93-1)

Guidance literature:

With sulfuric acid; In ethanol; for 1h; Reflux;

DOI:10.1016/j.bmc.2011.01.032

upstream raw materials:

2-((4-(4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline

methylhydrazine

3-(dimethylamino)-2-(pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)prop-2-en-1-one

2-Chloromethylquinoline

Downstream raw materials:

MP-10 succinate

Refernces

• 1、 Tu, Zhude,Fan, Jinda,Li, Shihong,Jones, Lynne A.,Cui, Jinquan,Padakanti, Prashanth K.,Xu, Jinbin,Zeng, Dexing,Shoghi, Kooresh I.,Perlmutter, Joel S.,MacH, Robert H.. "Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain". . p. 1666 - 1673. Retrieved 2011/04/16.
• 2、 -. "Heteroaromatic quinoline compounds". Page/Page column 24-25. . Retrieved 2008/06/13.