5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE
• CAS No.: 885280-83-1
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.156
• Mol file: 885280-83-1.mol

Synonyms:5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE

Chemical Property of 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 35.25000
• LogP: 1.91820

Purity/Quality:

98%min ^*data from raw suppliers

5-Fluoro-2,3-dihydro-benzofuran-3-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE

There total 3 articles about 5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H6FN3O → C8H8FNO (885280-83-1)

Guidance literature:

With water; In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.02.059

Reference yield:

5-fluoro-2,3-dihydro-benzofuran-3-ol (60770-60-7) → C8H8FNO (885280-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

2: water / tetrahydrofuran / 2 h / 50 °C

With diphenyl phosphoryl azide; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2012.02.059

Reference yield:

5-fluoro-2-hydroxybenzaldehyde (347-54-6) → C8H8FNO (885280-83-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 20 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

3: water / tetrahydrofuran / 2 h / 50 °C

With diphenyl phosphoryl azide; potassium tert-butylate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dimethyl sulfoxide; toluene;

DOI:10.1016/j.bmcl.2012.02.059

upstream raw materials:

5-fluoro-2,3-dihydro-benzofuran-3-ol

5-fluoro-2-hydroxybenzaldehyde

Downstream raw materials:

C₂₀H₁₈FN₃O₃

Refernces