N-(2-chlorophenyl)-N-methylacetamide

Base Information

• Chemical Name: N-(2-chlorophenyl)-N-methylacetamide
• CAS No.: 74585-34-5
• Molecular Formula: C9H10 Cl N O
• Molecular Weight: 183.6348
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID70370641
• Nikkaji Number: J1.304.216K
• Wikidata: Q82157768
• Mol file: 74585-34-5.mol

Synonyms:N-(2-chlorophenyl)-N-methylacetamide;74585-34-5;2'-Chloro-n-methylacetanilide;2'-Chloro-N-methylacetoanilide;SCHEMBL6393802;DTXSID70370641;AKOS024318913

Chemical Property of N-(2-chlorophenyl)-N-methylacetamide

Chemical Property:

• Boiling Point: 290oC at 760 mmHg
• Flash Point: 129.2oC
• PSA: 20.31000
• Density: 1.2g/cm3
• LogP: 2.32270
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 183.0450916
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

98%Min ^*data from raw suppliers

N-ACETYL-N-METHYL-2-CHLOROANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C)C1=CC=CC=C1Cl

Technology Process of N-(2-chlorophenyl)-N-methylacetamide

There total 5 articles about N-(2-chlorophenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ acetic acid-(2-chloro-N-methyl-anilide) (74585-34-5)

Guidance literature:

Reference yield:

o-chloroaniline (95-51-2) → acetic acid-(2-chloro-N-methyl-anilide) (74585-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 1 h / Heating

In benzene;

DOI:10.1021/ja00288a027

Reference yield:

N-(2-chlorophenyl)acetamide (533-17-5) → acetic acid-(2-chloro-N-methyl-anilide) (74585-34-5)

Guidance literature:

DOI:10.1021/ja00288a027

upstream raw materials:

N-methyl-2-chloroaniline

N-(2-chlorophenyl)acetamide

dimethyl sulfate

o-chloroaniline

Downstream raw materials:

N-methyl-2-indolinone

2-(N-acetyl-N-methylamino)phenol

N-methyl-2-chloroaniline

N-(2-chlorophenyl)-N-methylethenesulfonamide

Refernces

• 1、 Zhu, Manghong,Zhang, Chen,Nwachukwu, Jerome C.,Srinivasan, Sathish,Cavett, Valerie,Zheng, Yangfan,Carlson, Kathryn E.,Dong, Chune,Katzenellenbogen, John A.,Nettles, Kendall W.,Zhou, Hai-Bing. "Bicyclic core estrogens as full antagonists: Synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides". . p. 8692 - 8700. Retrieved 2013/01/15.
• 2、 Kalkote,Choudhary,Natu,Lahoti,Ayyangar. "Facile synthesis of substituted n-monoalkylaromatic amines under PTC conditions". . p. 1889 - 1900. Retrieved 2007/10/02.