4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol

Base Information

• Chemical Name: 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol
• CAS No.: 75934-17-7
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 75934-17-7.mol

Synonyms:4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol

Chemical Property of 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol

There total 5 articles about 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-iodobutyl)anisole (75934-24-6) → 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol (75934-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium tert-butylate / tert-butyl alcohol / 24 h / 90 °C

2: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 1) in dry ether at reflux for 1h 2) CO₂ as a continous stream for 1h

3: thionyl chloride

4: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 1) for 1h 2) at 50 deg C for 1h

With sodium hydroxide; n-butyllithium; thionyl chloride; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; dihydrogen peroxide; In tert-butyl alcohol;

DOI:10.1021/jo00317a027

Reference yield:

methoxybenzene (100-66-3) → 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol (75934-17-7)

Guidance literature:

Multi-step reaction with 5 steps

1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 1) in dry ether at reflux for 1h 2) -22 deg C overnight

2: potassium tert-butylate / tert-butyl alcohol / 24 h / 90 °C

3: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 1) in dry ether at reflux for 1h 2) CO₂ as a continous stream for 1h

4: thionyl chloride

5: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 1) for 1h 2) at 50 deg C for 1h

With sodium hydroxide; n-butyllithium; thionyl chloride; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; dihydrogen peroxide; In tert-butyl alcohol;

DOI:10.1021/jo00317a027

Reference yield:

2-<2-Methoxy-3-(butenyl)phenyl>-4,4-dimethyl-2-oxazoline (75934-04-2) → 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butan-1-ol (75934-17-7)

Guidance literature:

With sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide; Yield given. Multistep reaction; 1) for 1h 2) at 50 deg C for 1h;

DOI:10.1021/jo00317a027

upstream raw materials:

2-<2-Methoxy-3-(butenyl)phenyl>-4,4-dimethyl-2-oxazoline

1-(but-3-en-1-yl)-2-methoxybenzene

(4-iodobutyl)anisole

3-(3-Butenyl)anisic Acid

Downstream raw materials:

2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

2-[3-(4-Bromo-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid

Refernces