diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate
• CAS No.: 1334500-64-9
• Molecular Formula: C₁₅H₁₉F₃N₂O₄
• Molecular Weight: 348.322
• Mol file: 1334500-64-9.mol

Synonyms:diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate

Chemical Property of diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate

There total 4 articles about diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

di-isopropyl azodicarboxylate (2446-83-5) + 2-(trifluoromethyl)benzenamine (88-17-5) → diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate (1334500-64-9)

Guidance literature:

2-(trifluoromethyl)benzenamine; With tert.-butylnitrite; toluene-4-sulfonic acid; In dimethyl sulfoxide; at 25 ℃; for 0.166667h;

di-isopropyl azodicarboxylate; With iron(II) chloride; In dimethyl sulfoxide; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c5ra15875c

Reference yield: 82.0%

di-isopropyl azodicarboxylate (2446-83-5) + 2-iodo(trifluoromethyl)benzene (444-29-1) → diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate (1334500-64-9)

Guidance literature:

2-iodo(trifluoromethyl)benzene; With copper(l) iodide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1055/s-0030-1260802

Reference yield: 67.0%

di-isopropyl azodicarboxylate (2446-83-5) + o-trifluoromethylphenyl bromide (392-83-6) → diisopropyl 1-[2-(trifluromethyl)phenyl]-hydrazine-1,2-dicarboxylate (1334500-64-9)

Guidance literature:

di-isopropyl azodicarboxylate; o-trifluoromethylphenyl bromide; With copper(l) iodide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.12.036

upstream raw materials:

di-isopropyl azodicarboxylate

2-iodo(trifluoromethyl)benzene

2-trifluoromethyl-1-trifluoromethanesulfonyloxybenzene

2-(trifluoromethyl)benzenamine

Refernces

• 1、 Yavari, Issa,Ghazanfarpour-Darjani, Majid,Bayat, Mohammad J.,Malekafzali, Alaleh. "Sodium hydride induced N-arylation of diisopropyl azodicarboxylate by aryl trifluoromethanesulfonates". . p. 942 - 944. Retrieved 2015/04/27.
• 2、 Yavari, Issa,Ghazanfarpour-Darjani, Majid,Solgi, Yazdan,Ahmadian, Salome. "Copper(I) iodide catalyzed formation of aryl hydrazides from a mitsunobo reagent and aryl halides". supporting information; experimental part. p. 1745 - 1747. Retrieved 2011/09/16.