C₃₃H₅₄N₄O₁₁S₃

Base Information

• Chemical Name: C₃₃H₅₄N₄O₁₁S₃
• CAS No.: 1446499-23-5
• Molecular Formula: C₃₃H₅₄N₄O₁₁S₃
• Molecular Weight: 779.01
• Mol file: 1446499-23-5.mol

Synonyms:C₃₃H₅₄N₄O₁₁S₃

Chemical Property of C₃₃H₅₄N₄O₁₁S₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₅₄N₄O₁₁S₃

There total 4 articles about C₃₃H₅₄N₄O₁₁S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C22H42N2O6S3 (1446499-12-2) + 2-chloro-N-(1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide (17278-57-8) → C33H54N4O11S3 (1446499-23-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In tetrahydrofuran; at 40 ℃; for 16h;

DOI:10.1021/jm400707f

Reference yield:

clindamycin hydrochloride (21462-39-5,17431-55-9) → C33H54N4O11S3 (1446499-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

2: caesium carbonate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 16 h / 40 °C

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm400707f

Reference yield:

(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol (119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0) → C33H54N4O11S3 (1446499-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / methanol / 5 h / Cooling with ice

2: caesium carbonate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 16 h / 40 °C

With tetra-(n-butyl)ammonium iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

DOI:10.1021/jm400707f

upstream raw materials:

clindamycin hydrochloride

C₃₀H₅₀N₂O₁₀S₃

(1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

C₂₂H₄₂N₂O₆S₃

Refernces