C₁₅H₁₇FO₄

Base Information

• Chemical Name: C₁₅H₁₇FO₄
• CAS No.: 1369768-30-8
• Molecular Formula: C₁₅H₁₇FO₄
• Molecular Weight: 280.296
• Mol file: 1369768-30-8.mol

Synonyms:C₁₅H₁₇FO₄

Chemical Property of C₁₅H₁₇FO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₇FO₄

There total 5 articles about C₁₅H₁₇FO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + ((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol (1369767-20-3) → [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate (1369768-29-5) + C15H17FO4 (1369768-30-8)

Guidance literature:

With Candida Antarctica Lipase B; In 2-methyltetrahydrofuran; at 20 - 25 ℃; Inert atmosphere; Enzymatic reaction;

Reference yield:

(1S,2R)-1-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropane-1-carboxylic acid (1450905-00-6) → [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate (1369768-29-5) + C15H17FO4 (1369768-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 2 h / 60 °C

2: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere

3: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction

With hydrogenchloride; lithium borohydride; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;

Reference yield:

(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane (528587-70-4) → [(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate (1369768-29-5) + C15H17FO4 (1369768-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere

2: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction

With lithium borohydride; In tetrahydrofuran; 2-methyltetrahydrofuran;

upstream raw materials:

(1S,2R)-1-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane

vinyl acetate

((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Refernces