ETHYL 4-BROMO-3-NITROBENZOATE

Base Information

• Chemical Name: ETHYL 4-BROMO-3-NITROBENZOATE
• CAS No.: 168473-87-8
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.071
• Hs Code.: 2916399090
• Mol file: 168473-87-8.mol

Synonyms:Ethyl 4-bromo-3-nitrobenzoate;4-Bromo-3-nitro-benzoic acid ethyl ester;

Chemical Property of ETHYL 4-BROMO-3-NITROBENZOATE

Chemical Property:

• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 333.9 °C at 760 mmHg
• Flash Point: 155.7 °C
• PSA: 72.12000
• Density: 1.594 g/cm³
• LogP: 3.05720
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl4-bromo-3-nitrobenzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-BROMO-3-NITROBENZOATE

There total 1 articles about ETHYL 4-BROMO-3-NITROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Ethyl 4-bromobenzoate (5798-75-4) → ethyl 4-bromo-3-nitrobenzoate (168473-87-8)

Guidance literature:

With sulfuric acid; nitric acid; at -8 - 0 ℃; for 3.16667h;

DOI:10.1002/ejoc.202000599

Reference yield: 98.0%

ethyl 4-bromo-3-nitrobenzoate (168473-87-8) → 3-amino-4-bromobenzoic acid ethyl ester (168473-88-9)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; at 20 ℃; for 20h;

DOI:10.1002/ejoc.202000599

Reference yield: 75.0%

ethyl 4-bromo-3-nitrobenzoate (168473-87-8) + N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → C18H24N2O8 (1335114-88-9)

Guidance literature:

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; at 20 ℃;

ethyl 4-bromo-3-nitrobenzoate; With palladium diacetate; XPhos; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.tetlet.2011.07.083

upstream raw materials:

Ethyl 4-bromobenzoate

Downstream raw materials:

3-nitro-4-phenoxy-benzoic acid ethyl ester

ethyl 4-amino-3-nitrobenzoate

4-hydrazino-3-nitro-benzoic acid ethyl ester

ethyl 3-nitro-4-(phenylamino)benzoate

Refernces

• 1、 -. "SUBSTITUTED 1,2,4-TRIAZOLIN-3-ONE COMPOUNDS BEARING ACIDIC FUNCTIONAL GROUPS AS BALANCED ANGIOTENSIN II ANTAGONISTS". . . Retrieved 2008/06/13.