5-BROMO-3-FLUOROPICOLINIC ACID

Base Information

• Chemical Name: 5-BROMO-3-FLUOROPICOLINIC ACID
• CAS No.: 669066-91-5
• Molecular Formula: C6H3 Br F N O2
• Molecular Weight: 219.998
• Hs Code.: 2933399090
• Mol file: 669066-91-5.mol

Synonyms:5-Bromo-3-fluoropyridine-2-carboxylicacid

Chemical Property of 5-BROMO-3-FLUOROPICOLINIC ACID

Chemical Property:

• Melting Point: 175-180℃
• Boiling Point: 290.5±40.0 °C(Predicted)
• PKA: 2.48±0.10(Predicted)
• PSA: 50.19000
• Density: 1.903±0.06 g/cm3(Predicted)
• LogP: 1.68140
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-3-fluoropyridine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-3-FLUOROPICOLINIC ACID

There total 6 articles about 5-BROMO-3-FLUOROPICOLINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-fluoro-pyridine-2-carboxylic acid amide (669066-90-4) → 5-bromo-3-fluoro-pyridine-2-carboxylic acid (669066-91-5)

Guidance literature:

With hydrogenchloride; at 100 ℃;

DOI:10.1016/j.bmcl.2007.04.040

Reference yield:

5-bromo-3-fluoropyridine-2-carbonitrile (886373-28-0) → 5-bromo-3-fluoro-pyridine-2-carboxylic acid (669066-91-5)

Guidance literature:

With hydrogenchloride; water; at 60 ℃;

Reference yield:

3-amino-5-bromopyridine-2-carboxylic acid amide (669066-89-1) → 5-bromo-3-fluoro-pyridine-2-carboxylic acid (669066-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NOBF₄ / CH₂Cl₂

1.2: toluene / 100 °C

2.1: aq. HCl / 100 °C

With hydrogenchloride; nitrosonium tetrafluoroborate; In dichloromethane;

DOI:10.1016/j.bmcl.2007.04.040

upstream raw materials:

5-bromo-3-fluoro-pyridine-2-carboxylic acid amide

3-amino-5-bromopyridine-2-carboxylic acid amide

2,5-dibromo-3-nitro-pyridine

5-bromo-3-nitropyridine-2-carbonitrile

Downstream raw materials:

methyl 3-fluoro-5-hydroxypyridine-2-carboxylate

ethyl 3-amino-5-bromopyridine-2-carboxylate

Refernces

• 1、 -. "PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS". Page/Page column 89; 90. . Retrieved 2017/11/06.
• 2、 Kuduk, Scott D.,DiPardo, Robert M.,Chang, Ronald K.,Di Marco, Christina N.,Murphy, Kathy L.,Ransom, Richard W.,Reiss, Duane R.,Tang, Cuyue,Prueksaritanont, Thomayant,Pettibone, Douglas J.,Bock, Mark G.. "Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series". . p. 3608 - 3612. Retrieved 2008/02/08.