Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)
• CAS No.: 254-86-4
• Molecular Formula: C7H5 N3
• Molecular Weight: 131.137
• Hs Code.: 2933990090
• Mol file: 254-86-4.mol

Synonyms:1,4,6-Triazanaphthalene;6-Azaquinoxaline

Chemical Property of Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.00956mmHg at 25°C
• Melting Point: 97 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 273.5°C at 760 mmHg
• PKA: 3.60±0.10(Predicted)
• Flash Point: 128.7°C
• PSA: 38.67000
• Density: 1.27g/cm³
• LogP: 1.02480
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrido[3,4-B]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)

There total 4 articles about Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-diaminopyridine (54-96-6) + Glyoxal (131543-46-9,107-22-2) → pyrido[3,4-b]pyrazine (254-86-4)

Guidance literature:

In ethanol; water; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/chem.201204452

Reference yield:

→ 5-azaquinoxaline (322-46-3) + pyrido[3,4-b]pyrazine (254-86-4)

Guidance literature:

Reference yield:

3,4-diaminopyridine (54-96-6) + glyoxal sodium bisulfite (517-21-5) → pyrido[3,4-b]pyrazine (254-86-4)

Guidance literature:

With acetic acid; und Erhitzen des Reaktionsprodukts auf 240grad/15 Torr;

upstream raw materials:

3,4-diaminopyridine

Glyoxal

glyoxal sodium bisulfite

Downstream raw materials:

C₂₃H₂₁N₃O₄S₂

2-(Toluene-4-sulfonylmethyl)-pyrido[3,4-b]pyrazine

C₂₅H₂₅N₃O₄S₂

2-Phenylsulfanylmethyl-pyrido[3,4-b]pyrazine

Refernces

• 1、 -. "Substituted ring compound and its method and use thereof". Paragraph 0876; 0877; 0878; 0879. . Retrieved 2017/08/25.
• 2、 Horne, Daniel B.,Tamayo, Nuria A.,Bartberger, Michael D.,Bo, Yunxin,Clarine, Jeffrey,Davis, Carl D.,Gore, Vijay K.,Kaller, Matthew R.,Lehto, Sonya G.,Ma, Vu V.,Nishimura, Nobuko,Nguyen, Thomas T.,Tang, Phi,Wang, Weiya,Youngblood, Beth D.,Zhang, Maosheng,Gavva, Narender R.,Monenschein, Holger,Norman, Mark H.. "Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists". . p. 2989 - 3004. Retrieved 2014/05/06.