2-Hydrazinyl-6-methylpyridine

Base Information

• Chemical Name: 2-Hydrazinyl-6-methylpyridine
• CAS No.: 5315-24-2
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 2933990090
• European Community (EC) Number: 827-058-7
• DSSTox Substance ID: DTXSID60544536
• Wikidata: Q82421660
• Mol file: 5315-24-2.mol

Synonyms:2-Hydrazinyl-6-methylpyridine;5315-24-2;(6-methylpyridin-2-yl)hydrazine;2-METHYL-6-HYDRAZINOPYRIDINE;2-hydrazino-6-methylpyridine;1-(6-methylpyridin-2-yl)hydrazine;MFCD07786311;2-hydrazinyl-6-methylpyridine;(6-METHYL-PYRIDIN-2-YL)-HYDRAZINE;2(1H)-Pyridinone, 6-methyl-, hydrazone;propylidynetrimethyltrinitrate;SCHEMBL2007460;SCHEMBL23873843;DTXSID60544536;RDVGWJKUYXVTSO-UHFFFAOYSA-N;AKOS010096078;AM87040;CS-W021701;SB52357;AS-30717;SY107497;EN300-83040;A870810;J-509587

Chemical Property of 2-Hydrazinyl-6-methylpyridine

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 54-56 °C
• Refractive Index: 1.633
• Boiling Point: 262.196°C at 760 mmHg
• PKA: 9.73±0.70(Predicted)
• Flash Point: 112.372°C
• PSA: 50.94000
• Density: 1.167g/cm³
• LogP: 1.44890
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydrazinyl-6-methylpyridine 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)NN

Technology Process of 2-Hydrazinyl-6-methylpyridine

There total 5 articles about 2-Hydrazinyl-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-fluoro-6-methylpyridine (407-22-7) → 1-(6-methylpyridin-2-yl)hydrazine (5315-24-2)

Guidance literature:

With hydrazine hydrate; In 2-ethoxy-ethanol; for 16h; Reflux;

DOI:10.1002/cmdc.201700783

Reference yield: 72.0%

6-chloro-2-picoline (18368-63-3) → 1-(6-methylpyridin-2-yl)hydrazine (5315-24-2)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.tetlet.2020.151844

Reference yield: 72.0%

2-chloro-6-methylpyrazine (38557-71-0) → 1-(6-methylpyridin-2-yl)hydrazine (5315-24-2)

Guidance literature:

With hydrazine hydrate; at 100 ℃; for 2h;

DOI:10.2174/1570178611310050008

upstream raw materials:

2-bromo-6-methylpyridine

2-fluoro-6-methylpyridine

6-chloro-2-picoline

2-chloro-6-methylpyrazine

Downstream raw materials:

4-[1-(6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-[1,2,4]triazol-3-yl]-benzonitrile

3-(trifluoromethyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine

5-methyl-[1,2,4]triazolo[4,3-a]pyridine

2-methyl-6-(phenylethynyl)pyridine

Refernces

• 1、 -. "Pyrazolo-cyclic compound, pharmaceutical composition containing pyrazolo-cyclic compound, and preparation method and application of pyrazolo-cyclic compound". Paragraph 0408-0412. . Retrieved 2021/04/26.
• 2、 -. "ASK1 inhibitor and application thereof". Paragraph 0169-0173. . Retrieved 2020/02/10.