Magnesium chloride (2-methoxyphenyl)methanide (1/1/1)

Base Information

• Chemical Name: Magnesium chloride (2-methoxyphenyl)methanide (1/1/1)
• CAS No.: 480438-46-8
• Molecular Formula: C8H9ClMgO
• Molecular Weight: 180.917
• Hs Code.: 29310099
• DSSTox Substance ID: DTXSID30514842
• Mol file: 480438-46-8.mol

Synonyms:Magnesium chloride (2-methoxyphenyl)methanide (1/1/1);magnesium;1-methanidyl-2-methoxybenzene;chloride;DTXSID30514842

Chemical Property of Magnesium chloride (2-methoxyphenyl)methanide (1/1/1)

Chemical Property:

• Refractive Index: ">
• Boiling Point: 65 °C
• Flash Point: 1 °F
• PSA: 9.23000
• Density: 0.910 g/mL at 25 °C
• LogP: 2.70040
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Solubility.: Miscible with tetrahydrofuran.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 180.0192343
• Heavy Atom Count: 11
• Complexity: 80.6

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxybenzylmagnesium chloride solution 0.25M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F;C
• Hazard Codes: F,C
• Statements: 11-14-19-22-34-40-37
• Safety Statements: 16-26-33-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1[CH2-].[Mg+2].[Cl-]
• Uses: 2-Methoxybenzylmagnesium chloride is a Grignard reagent used in organic synthesis. It is involved in the synthesis of (-)-Chamobtusin A. It is also used in the preparation of molybdenum and tungsten Alkylidene complexes having a tert-butylimido ligand.

Technology Process of Magnesium chloride (2-methoxyphenyl)methanide (1/1/1)

There total 2 articles about Magnesium chloride (2-methoxyphenyl)methanide (1/1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-Methoxybenzyl chloride (7035-02-1) → Grignard reagent from 2-methoxybenzyl chloride (480438-46-8)

Guidance literature:

With magnesium; In diethyl ether;

DOI:10.1016/S0040-4020(01)88438-6

Reference yield:

o-Methoxybenzyl chloride (7035-02-1) → 1,2-bis(2-methoxyphenyl)ethane (14310-34-0) + Grignard reagent from 2-methoxybenzyl chloride (480438-46-8)

Guidance literature:

With magnesium; In tetrahydrofuran;

DOI:10.1107/S0108270193014544

Reference yield: 93.0%

2-methoxy-N-methoxy-N-methylbenzamide (130250-62-3) + Grignard reagent from 2-methoxybenzyl chloride (480438-46-8) → 1-(2-methoxyphenyl)-2-(2-methoxyphenyl)ethanone (66659-59-4)

Guidance literature:

2-methoxy-N-methoxy-N-methylbenzamide; Grignard reagent from 2-methoxybenzyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1002/bkcs.10806

upstream raw materials:

o-Methoxybenzyl chloride

Downstream raw materials:

2-[1-Hydroxy-2-(2-methoxy-phenyl)-ethyl]-phenol

4-[4-(2-methoxybenzyl)-4-hydroxy-piperidin-1-yl]-benzoic acid ethyl ester

4-[4-(2-methoxybenzyl)-4-methoxy-piperidin-1-yl]-benzoic acid ethyl ester

3-(2-methoxy-benzyl)-4-(4-methoxy-phenyl)-furan-2,5-dione

Refernces

• 1、 Ross, Jennifer-Nicola,Wardell, James,Ferguson, George,Low, John N.. "2,2'-Dimethoxybibenzyl". . p. 976 - 977. Retrieved 2007/10/02.