1,2-Bis(2-methoxyphenyl)ethanone

Base Information

• Chemical Name: 1,2-Bis(2-methoxyphenyl)ethanone
• CAS No.: 66659-59-4
• Molecular Formula: C16H16O3
• Molecular Weight: 256.301
• Hs Code.: 2914509090
• NSC Number: 26661
• DSSTox Substance ID: DTXSID20282583
• Nikkaji Number: J3.200.001K
• Wikidata: Q82016896
• Mol file: 66659-59-4.mol

Synonyms:1,2-bis(2-methoxyphenyl)ethanone;66659-59-4;MLS002639140;NSC26661;SCHEMBL332837;DTXSID20282583;HMS3080K23;NSC-26661;SMR001548591

Chemical Property of 1,2-Bis(2-methoxyphenyl)ethanone

Chemical Property:

• Vapor Pressure: 3.9E-06mmHg at 25°C
• Melting Point: 57 °C
• Refractive Index: 1.558
• Boiling Point: 385.1 °C at 760 mmHg
• Flash Point: 178.2 °C
• PSA: 35.53000
• Density: 1.115 g/cm³
• LogP: 3.12920
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.109944368
• Heavy Atom Count: 19
• Complexity: 290

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1CC(=O)C2=CC=CC=C2OC

Technology Process of 1,2-Bis(2-methoxyphenyl)ethanone

There total 10 articles about 1,2-Bis(2-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,2-bis(2-methoxyphenyl)ethene (17601-37-5) → 1-(2-methoxyphenyl)-2-(2-methoxyphenyl)ethanone (66659-59-4)

Guidance literature:

With hydrogenchloride; oxygen; palladium dichloride; In methanol; water; at 20 ℃; for 72h; under 760.051 Torr; pH=1 - 1.5;

DOI:10.1016/j.jorganchem.2013.05.008

Reference yield: 93.0%

2-methoxy-N-methoxy-N-methylbenzamide (130250-62-3) + Grignard reagent from 2-methoxybenzyl chloride (480438-46-8) → 1-(2-methoxyphenyl)-2-(2-methoxyphenyl)ethanone (66659-59-4)

Guidance literature:

2-methoxy-N-methoxy-N-methylbenzamide; Grignard reagent from 2-methoxybenzyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1002/bkcs.10806

Reference yield: 42.9%

(2-methoxyphenyl)methanol (612-16-8) → 1-(2-methoxyphenyl)-2-(2-methoxyphenyl)ethanone (66659-59-4)

Guidance literature:

With Zn_0.6In₂S_3.6; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere; Sealed tube; Irradiation;

upstream raw materials:

2,2'-dimethoxybenzoin

2,2',α-trimethoxy-deoxybenzoin

α-chloro-2,2'-dimethoxy-deoxybenzoin

2-Methoxybenzoyl chloride

Downstream raw materials:

3,4-bis-(2-methoxy-phenyl)-cyclohex-2-enone

2-(benzofuran-2-yl)phenol

2,2'-dimethoxy-deoxybenzoin oxime

2-benzofuran-2-yl-4,6-dinitro-phenol

Refernces

• 1、 Lee, Jae In. "An efficient and versatile synthesis of isoflavones from 2-methoxybenzoic acids". . p. 1132 - 1135. Retrieved 2016/07/15.
• 2、 Dang, Y.,Geise, H. J.. "REDUCTIVE COUPLING OF BENZOIC ACID HALIDES AND ESTERS USING LOW-VALENT TITANIUM". . p. 375 - 380. Retrieved 2007/10/02.