tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate
• CAS No.: 236406-22-7
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 2933399090
• Mol file: 236406-22-7.mol

Synonyms:1-piperid;LogP

Chemical Property of tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.000855mmHg at 25°C
• Refractive Index: 1.476
• Boiling Point: 304.8 °C at 760 mmHg
• Flash Point: 138.1 °C
• PSA: 55.56000
• Density: 1.002 g/cm³
• LogP: 2.62050
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(Aminomethyl)-4-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate

There total 9 articles about tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-cyano-4-methylpiperidine-1-carboxylic acid tert-butyl ester (530115-96-9) → tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate (236406-22-7)

Guidance literature:

With ammonia; hydrogen; 5% Rh/Al2O3; In methanol; under 2068.65 Torr;

Reference yield:

N-tert-butyloxycarbonyl-4-azidomethyl-4-methylpiperidine → tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate (236406-22-7)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 0 ℃; for 16h;

DOI:10.1016/j.ejmech.2015.08.051

Reference yield:

N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde (189442-92-0) → tert-butyl 4-(aminomethyl)-4-methylpiperidine-1-carboxylate (236406-22-7)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol;

upstream raw materials:

4-cyano-4-methylpiperidine-1-carboxylic acid tert-butyl ester

N-tert-Butoxycarbonyl-4-methyl-4-piperidine carboxaldehyde

4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Refernces

• 1、 Nirogi, Ramakrishna,Mohammed, Abdul Rasheed,Shinde, Anil K.,Bogaraju, Narsimha,Gagginapalli, Shankar Reddy,Ravella, Srinivasa Rao,Kota, Laxman,Bhyrapuneni, Gopinadh,Muddana, Nageswara Rao,Benade, Vijay,Palacharla, Raghava Chowdary,Jayarajan, Pradeep,Subramanian, Ramkumar,Goyal, Vinod Kumar. "Synthesis and SAR of Imidazo[1,5-a[pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease". . p. 289 - 301. Retrieved 2015/09/21.
• 2、 Budzik, Brian,Garzya, Vincenzo,Shi, Dongchuan,Foley, James J.,Rivero, Ralph A.,Langmead, Christopher J.,Watson, Jeannette,Wu, Zining,Forbes, Ian T.,Jin, Jian. "2′ Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR". scheme or table. p. 3540 - 3544. Retrieved 2010/08/22.