METHYL 3-FLUOROISONICOTINATE

Base Information

• Chemical Name: METHYL 3-FLUOROISONICOTINATE
• CAS No.: 876919-08-3
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.129
• Hs Code.: 2933399090
• Mol file: 876919-08-3.mol

Synonyms:3-Fluoroisonicotinicacid methyl ester;Methyl 3-fluoroisonicotinate;Methyl3-fluoropyridine-4-carboxylate;

Chemical Property of METHYL 3-FLUOROISONICOTINATE

Chemical Property:

• Vapor Pressure: 0.233mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 206.8 °C at 760 mmHg
• PKA: 0.69±0.18(Predicted)
• Flash Point: 78.9 °C
• PSA: 39.19000
• Density: 1.243g/cm³
• LogP: 1.00730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-Fluoroisonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-FLUOROISONICOTINATE

There total 4 articles about METHYL 3-FLUOROISONICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 3-fluoroisonicotinic acid (393-53-3) → methyl 3-fluoropyridine-4-carboxylate (876919-08-3)

Guidance literature:

methanol; 3-fluoroisonicotinic acid; With sulfuric acid; at 70 ℃;

With sodium carbonate; In water; at 0 ℃; pH=9;

Reference yield: 94.0%

→ methyl 3-fluoropyridine-4-carboxylate (876919-08-3)

Guidance literature:

Reference yield: 88.0%

methanol (67-56-1) → methyl 3-fluoropyridine-4-carboxylate (876919-08-3)

Guidance literature:

3-fluoroisonicotinic acid; With thionyl chloride; for 1h; Heating / reflux;

methanol; for 1h; Heating / reflux;

upstream raw materials:

methyl 3-nitropyridine-4-carboxylate

methanol

3-fluoroisonicotinic acid

Downstream raw materials:

methyl 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylate

2-trifluoromethyl-3-fluoro-4-pyridinecarboxylic acid

3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl]methyl}amino)pyridine-4-carboxylic acid

methyl 3-(((1S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohexyl)amino)isonicotinate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)". Page/Page column 163-164. . Retrieved 2021/06/22.
• 2、 -. "Preparation method of 2-trifluoromethyl-3-fluoro-4-picolinic acid and derivatives thereof". Paragraph 0043-0047. . Retrieved 2020/04/17.