Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate

Base Information

• Chemical Name: Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate
• CAS No.: 1227594-82-2
• Molecular Formula: C₈H₅F₄NO₂
• Molecular Weight: 223.127
• Hs Code.: 2933399990
• Mol file: 1227594-82-2.mol

Synonyms:

Chemical Property of Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate

Chemical Property:

• Boiling Point: 221.5±40.0 °C(Predicted)
• PKA: -4.01±0.30(Predicted)
• Density: 1.409±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Fluoro-2-(trifluoromethyl)pyridine-4-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate

There total 2 articles about Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-fluoropyridine-4-carboxylate (876919-08-3) + Langlois reagent (2926-29-6) → methyl 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylate (1227594-82-2)

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane; water; at 20 ℃; for 12h;

Reference yield:

methanol (67-56-1) + 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylic acid (886510-09-4) → methyl 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylate (1227594-82-2)

Guidance literature:

With sulfuric acid; at 20 - 60 ℃;

Reference yield:

methyl 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylate (1227594-82-2) → [3-fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol (1227600-70-5)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃;

upstream raw materials:

methanol

2-trifluoromethyl-3-fluoro-4-pyridinecarboxylic acid

methyl 3-fluoropyridine-4-carboxylate

Langlois reagent

Downstream raw materials:

[3-fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol

Refernces

• 1、 -. "Preparation method of 2-trifluoromethyl-3-fluoro-4-picolinic acid and derivatives thereof". Paragraph 0038-0042; 0043; 0048-0051; 0057-0061. . Retrieved 2020/04/17.