5-Bromo-2-pyrazol-1-yl-pyrimidine

Base Information

• Chemical Name: 5-Bromo-2-pyrazol-1-yl-pyrimidine
• CAS No.: 883230-94-2
• Molecular Formula: C₇H₅BrN₄
• Molecular Weight: 225.047
• Hs Code.: 2933990090
• Mol file: 883230-94-2.mol

Synonyms:5-bromo-2-pyrazol-1-ylpyrimidine

Chemical Property of 5-Bromo-2-pyrazol-1-yl-pyrimidine

Chemical Property:

• Boiling Point: 402.2 °C at 760 mmHg
• Flash Point: 197 °C
• PSA: 43.60000
• Density: 1.79g/cm³
• LogP: 1.42480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-2-(1H-pyrazol-1-yl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-pyrazol-1-yl-pyrimidine

There total 5 articles about 5-Bromo-2-pyrazol-1-yl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

NH-pyrazole (288-13-1) + 5-Bromo-2-chloropyrimidine (32779-36-5) → 5-bromo-2-(1H-pyrazol-1-yl)pyrimidine (883230-94-2)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5ra18653f

Reference yield: 62.0%

NH-pyrazole (288-13-1) + 1-(5-bromopyrimidin-2-yl)-1H-benzo[d]imidazole (883230-69-1) → 5-bromo-2-(1H-pyrazol-1-yl)pyrimidine (883230-94-2)

Guidance literature:

With caesium carbonate; copper(II) nitrate; In N,N-dimethyl-formamide; at 130 ℃; for 24h; chemoselective reaction; Schlenk technique;

DOI:10.1055/s-0036-1590893

Reference yield: 53.0%

NH-pyrazole (288-13-1) + 5-bromo-2-(1H-imidazol-1-yl)pyrimidine (883230-68-0) → 5-bromo-2-(1H-pyrazol-1-yl)pyrimidine (883230-94-2)

Guidance literature:

With caesium carbonate; copper(II) nitrate; In N,N-dimethyl-formamide; at 130 ℃; for 24h; chemoselective reaction; Schlenk technique;

DOI:10.1055/s-0036-1590893

upstream raw materials:

NH-pyrazole

5-Bromo-2-chloropyrimidine

1-(5-bromopyrimidin-2-yl)-1H-benzo[d]imidazole

5-bromo-2-(1H-imidazol-1-yl)pyrimidine

Refernces

• 1、 Tao, Sheng,Ji, Enhui,Shi, Lei,Liu, Ning,Xu, Liang,Dai, Bin. "Copper-Catalyzed C-N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores". . p. 5120 - 5130. Retrieved 2017/11/28.
• 2、 -. "NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF". Paragraph 0901; 0902; 0903; 0904. . Retrieved 2014/10/29.