2-(4-METHYL-1-PIPERAZINYL)-4-PYRIMIDINAMINE

Base Information

• Chemical Name: 2-(4-METHYL-1-PIPERAZINYL)-4-PYRIMIDINAMINE
• CAS No.: 57005-71-7
• Molecular Formula: C9H15 N5
• Molecular Weight: 193.24900
• Hs Code.: 2933990090
• Mol file: 57005-71-7.mol

Synonyms:2-(4-Methylpiperazin-1-yl)pyrimidin-4-amine

Chemical Property of 2-(4-METHYL-1-PIPERAZINYL)-4-PYRIMIDINAMINE

Chemical Property:

• Vapor Pressure: 3.57E-06mmHg at 25°C
• Boiling Point: 386.3oC at 760 mmHg
• Flash Point: 187.4oC
• PSA: 58.28000
• Density: 1.196g/cm3
• LogP: 0.39470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-methyl-1-piperazinyl)-4-pyrimidinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-METHYL-1-PIPERAZINYL)-4-PYRIMIDINAMINE

There total 2 articles about 2-(4-METHYL-1-PIPERAZINYL)-4-PYRIMIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-methyl-piperazine (109-01-3) + 2-chloropyrimidin-4-amine (7461-50-9) → 2-(4-methyl-1-piperazinyl)-4-pyrimidinamine (57005-71-7)

Guidance literature:

In ethanol; at 150 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

DOI:10.1021/acsinfecdis.7b00212

Reference yield:

→ 2-(4-methyl-1-piperazinyl)-4-pyrimidinamine (57005-71-7)

Guidance literature:

Reference yield: 35.0%

formic acid (64-18-6) + 2-(4-methyl-1-piperazinyl)-4-pyrimidinamine (57005-71-7) + 7-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinolin-4-amine → N4-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-N7-(2-(4-methylpiperazin-1-yl)pyrimidin-4-yl)quinoline-4,7-diamine bis-formate

Guidance literature:

2-(4-methyl-1-piperazinyl)-4-pyrimidinamine; 7-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)quinolin-4-amine; With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; Inert atmosphere; Sealed tube; Microwave irradiation;

formic acid; In water; acetonitrile;

DOI:10.1021/acsinfecdis.7b00212

upstream raw materials:

1-methyl-piperazine

2-chloropyrimidin-4-amine

Refernces

• 1、 -. "INHIBITORS OF MUTANT FORMS OF EGFR". Page/Page column 45. . Retrieved 2021/07/02.
• 2、 -. "PEPTIDE DEFORMYLASE INHIBITORS". Page/Page column. . Retrieved 2014/02/15.