DL-MANDELAMIDE

Base Information

• Chemical Name: DL-MANDELAMIDE
• CAS No.: 4358-86-5
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• Mol file: 4358-86-5.mol

Synonyms:Benzeneacetamide, α-hydroxy-;dl-Mandelamide;mandelamide;DL-Mandelamide, 98%;

Chemical Property of DL-MANDELAMIDE

Chemical Property:

• Vapor Pressure: 2.33E-05mmHg at 25°C
• Melting Point: 133-137 °C(lit.)
• Refractive Index: 1.589
• Boiling Point: 345.5 °C at 760 mmHg
• Flash Point: 162.7 °C
• PSA: 63.32000
• Density: 1.246 g/cm³
• LogP: 0.90560

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-MANDELAMIDE

There total 96 articles about DL-MANDELAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-cicloesil-α-ossofenilacetamide (724-92-5) → (RS)-mandelamide (4410-31-5,24008-62-6,24008-63-7,4358-86-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4)

Guidance literature:

With sulfuric acid; In ethanol; water; Product distribution; Mechanism; Irradiation; other solvents;

DOI:10.1039/P19810001357

Reference yield: 46.0%

MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → (S)-Mandelic acid (17199-29-0) + (2R)-mandelamide (4358-86-5,4410-31-5,24008-63-7,24008-62-6) + (R)-Mandelic Acid (611-71-2)

Guidance literature:

With ammonium bicarbonate; In water; dimethyl sulfoxide; at 50 ℃; for 8h; Time; Reagent/catalyst; Temperature; Enzymatic reaction;

DOI:10.3109/10242422.2014.971120

Reference yield:

water rose + ammonium mandelate (530-31-4) → (RS)-mandelamide (4410-31-5,24008-62-6,24008-63-7,4358-86-5) + MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; water;

upstream raw materials:

2-oxo-2-phenylacetamide

(RS)-methyl mandelate

N-benzylidene-mandelamide

(RS)-mandelonitrile

Downstream raw materials:

(2R)-mandelamide

2-(Methyl-di-O-acetyl-α-D-glucopyranuronosyl-1,2-acetylidenoxy)-2-phenylacetamid

2-(Methyl-2,3,4-tri-O-acetyl-β-D-glucopyranuronosyloxy)-2-phenylacetamid

D-2-(Methyl-2,3,4-tri-O-acetyl-β-D-glucopyranuronosyloxy)-2-phenylacetamid

Refernces

• 1、 -. "Catalyst, preparation method thereof and preparation method of amide compound". Paragraph 0142-0146; 0147. . Retrieved 2020/01/12.
• 2、 Kanda, Tomoya,Naraoka, Asuka,Naka, Hiroshi. "Catalytic Transfer Hydration of Cyanohydrins to α-Hydroxyamides". supporting information. p. 825 - 830. Retrieved 2019/01/14.