4α-Aminocyclohexan-1α-ol

Base Information

• Chemical Name: 4α-Aminocyclohexan-1α-ol
• CAS No.: 40525-78-8
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Hs Code.: 2922199090
• Mol file: 40525-78-8.mol

Synonyms:4-Aminocyclohexanol;Cyclohexanol, 4-amino-;4-Aminocyclohexan-1-ol;trans-4-Aminocyclohexanol;Cyclohexanol, 4-amino-, trans-;nchembio.87-comp52;AC1Q4UBN;AC1Q4UBO;AC1Q7AEQ;

Chemical Property of 4α-Aminocyclohexan-1α-ol

Chemical Property:

• Melting Point: 201.1 °C at 760 mmHg
• Boiling Point: 75.4 °C
• PKA: 15.12±0.40(Predicted)
• PSA: 46.25000
• Density: 1.037 g/cm³
• LogP: 0.94890

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-4-Aminocyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4α-Aminocyclohexan-1α-ol

There total 8 articles about 4α-Aminocyclohexan-1α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → trans-1,4-cyclohexyldiamine (2615-25-0) + cis-1,4-cyclohexanediamine (15827-56-2) + trans-4-hydroxycyclohexylamine (27489-62-9) + cis-4-aminocyclohexanol (6850-65-3,27489-62-9,40525-78-8)

Guidance literature:

With methanol; 5% Rh/C; ammonia; hydrogen; isopropyl alcohol; In Hexadecane; at 140 ℃; for 3h; under 4500.45 Torr; Autoclave;

DOI:10.1002/cctc.201800486

Reference yield:

hydroquinone (123-31-9,8027-02-9) → trans-4-hydroxycyclohexylamine (27489-62-9) + cis-4-aminocyclohexanol (6850-65-3,27489-62-9,40525-78-8)

Guidance literature:

With methanol; 5% Rh/C; ammonia; hydrogen; isopropyl alcohol; In Hexadecane; at 140 ℃; for 3h; under 4500.45 Torr; Overall yield = 89 %Chromat.; Autoclave;

DOI:10.1002/cctc.201800486

Reference yield:

4-amino-phenol (123-30-8) → trans-4-hydroxycyclohexylamine (27489-62-9) + cis-4-aminocyclohexanol (6850-65-3,27489-62-9,40525-78-8)

Guidance literature:

With water; pyrographite; ruthenium; Hydrogenation;

DOI:10.1021/ja01556a061

upstream raw materials:

4-nitro-phenol

cis-(N-4-hydroxycyclohexyl)acetamide

4-amino-phenol

1-methyl-4-nitrosobenzene

Downstream raw materials:

cis-(4-hydroxycyclohexyl)carbamic acid tert-butyl ester

(1s,4s)-4-(piperazin-1-yl)cyclohexanol

ethyl 6-chloro-4-(((1s,4s)-4-hydroxycyclohexyl)amino)nicotinate

Refernces