3-Bromo-5-Chlorobenzotrifluoride

Base Information

• Chemical Name: 3-Bromo-5-Chlorobenzotrifluoride
• CAS No.: 928783-85-1
• Molecular Formula: C7H3BrClF3
• Molecular Weight: 259.453
• Hs Code.: 2903999090
• Mol file: 928783-85-1.mol

Synonyms:1-Bromo-3-chloro-5-(trifluoromethyl)benzene;

Chemical Property of 3-Bromo-5-Chlorobenzotrifluoride

Chemical Property:

• Vapor Pressure: 1.15mmHg at 25°C
• Boiling Point: 182℃
• Flash Point: 64℃
• PSA: 0.00000
• Density: 1.717
• LogP: 4.12130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-3-chloro-5-(trifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-5-Chlorobenzotrifluoride

There total 3 articles about 3-Bromo-5-Chlorobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-chloro-6-(trifluoromethyl)aniline (870703-71-2) → 1-bromo-3-chloro-5-(trifluoromethyl)benzene (928783-85-1)

Guidance literature:

4-bromo-2-chloro-6-(trifluoromethyl)aniline; With sulfuric acid; In water; at 20 - 30 ℃;

With sodium nitrite; In water; at 0 - 5 ℃;

With phosphinic acid; In water; at 20 - 30 ℃; Reagent/catalyst;

Reference yield:

2-(trifluoromethyl)benzenamine (88-17-5) → 1-bromo-3-chloro-5-(trifluoromethyl)benzene (928783-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine chloride; iron / dichloromethane / 17 h / 0 - 5 °C

2.1: thionyl chloride / dichloromethane / 12 h / 25 - 30 °C

3.1: sulfuric acid / water / 20 - 30 °C

3.2: 0 - 5 °C

3.3: 20 - 30 °C

With thionyl chloride; sulfuric acid; bromine chloride; iron; In dichloromethane; water;

Reference yield:

4-bromo-2-trifluoromethyl-aniline (445-02-3) → 1-bromo-3-chloro-5-(trifluoromethyl)benzene (928783-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 12 h / 25 - 30 °C

2.1: sulfuric acid / water / 20 - 30 °C

2.2: 0 - 5 °C

2.3: 20 - 30 °C

With thionyl chloride; sulfuric acid; In dichloromethane; water;

upstream raw materials:

2-(trifluoromethyl)benzenamine

4-bromo-2-chloro-6-(trifluoromethyl)aniline

4-bromo-2-trifluoromethyl-aniline

Downstream raw materials:

1-(3-chloro-5-(trifluoromethyl)phenyl)piperazine

1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one

(2E)-3-[4-(cyclopropylcarbamoyl)-3-trifluoromethylphenyl]acrylic acid

1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethanamine

Refernces