Technology Process of 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
There total 8 articles about 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N1-methyl-4-((2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yl)oxy)benzene-1,2-diamine; 4-(trifluoromethyl)phenyl isothiocyanate;
In
acetonitrile;
at 20 ℃;
for 0.333333h;
With
2-chloro-1-methyl-pyridinium iodide; triethylamine;
In
acetonitrile;
at 50 ℃;
for 5h;
Product distribution / selectivity;
- Guidance literature:
-
4-[1-methyl-2-(4-(trifluoromethyl)phenylamino)-1H-benzoimidazol-5-yloxy]-pyridine-2-carbonitrile;
With
sodium methylate;
In
isopropyl alcohol;
at 50 ℃;
for 1h;
3-bromo-1,1,1-trifluoroacetone;
With
ammonium acetate;
In
isopropyl alcohol;
at 70 - 85 ℃;
for 23h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: manganese(IV) oxide / chloroform / 48 h / 20 °C
2.1: sodium acetate / water / 0.67 h / 100 °C
2.2: 20 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 48 h
4.1: methanol / 16 h / 20 °C
4.2: 20 °C
With
manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; sodium acetate;
In
methanol; chloroform; water; ethyl acetate;
DOI:10.1021/ml500526p
