9-Bromo-1-nonene

Base Information

• Chemical Name: 9-Bromo-1-nonene
• CAS No.: 89359-54-6
• Molecular Formula: C9H17Br
• Molecular Weight: 205.138
• Hs Code.: 2903399090
• European Community (EC) Number: 807-610-3
• DSSTox Substance ID: DTXSID00452146
• Nikkaji Number: J599.123D
• Wikidata: Q72448840
• Mol file: 89359-54-6.mol

Synonyms:9-Bromo-1-nonene;9-bromonon-1-ene;89359-54-6;1-Nonene, 9-bromo-;1-bromo-8-nonene;Non-8-enyl Bromide;MFCD09037826;8-Nonenyl Bromide;9-bromanylnon-1-ene;SCHEMBL517698;DTXSID00452146;RQXPBVHYVAOUBY-UHFFFAOYSA-N;BBL103369;GEO-00531;STL557179;AKOS015836157;CS-W006397;AS-10141;SY105453;B3256;FT-0702771;EN300-317077;I11993;A843141

Chemical Property of 9-Bromo-1-nonene

Chemical Property:

• Refractive Index: 1.4675
• Boiling Point: 219.4 °C at 760 mmHg
• Flash Point: 90 °C
• PSA: 0.00000
• Density: 1.106 g/cm³
• LogP: 3.90790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 7
• Exact Mass: 204.05136
• Heavy Atom Count: 10
• Complexity: 69.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

Non-8-enylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CCCCCCCCBr
• Uses: Non-8-enyl Bromide is a reactant in the synthesis of breast cancer drug, Fulvestrant (Falsodex).

Technology Process of 9-Bromo-1-nonene

There total 12 articles about 9-Bromo-1-nonene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1 ,6-dibromohexane (629-03-8) + allylmagnesium bromide (1730-25-2) → 9-bromo-1-nonene (89359-54-6)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran;

DOI:10.1002/jccs.201100587

Reference yield: 76.0%

non-8-en-1-ol (13038-21-6) → 9-bromo-1-nonene (89359-54-6)

Guidance literature:

With 1H-imidazole; carbon tetrabromide; triphenylphosphine; In dichloromethane; at -30 - 30 ℃;

DOI:10.1016/j.tetlet.2013.05.029

Reference yield: 67.0%

1,9-Dibromononane (4549-33-1) → 9-bromo-1-nonene (89359-54-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 16h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2018.06.031

upstream raw materials:

non-8-en-1-ol

Methyltriphenylphosphonium bromide

8-bromo-1-octanal

1 ,6-dibromohexane

Downstream raw materials:

C₁₉H₂₈O₃

1-bromo-9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonane

methyl 9-decenoate

dec-9-enoic acid

Refernces

• 1、 -. "PROCESS AND INTERMEDIADES FOR THE PREPARATION OF 7-ALKYLATED STEROIDS". Page/Page column 51. . Retrieved 2015/12/17.
• 2、 Wang, Chun-Yi,Hou, Duen-Ren. "Asymmetric synthesis of (+)-aspicilin". scheme or table. p. 389 - 393. Retrieved 2012/08/08.