4-Nitro-2,6-pyridinedicarboxylic acid

Base Information

• Chemical Name: 4-Nitro-2,6-pyridinedicarboxylic acid
• CAS No.: 63897-10-9
• Molecular Formula: C7H4N2O6
• Molecular Weight: 212.12
• Hs Code.: 2933399090
• Mol file: 63897-10-9.mol

Synonyms:3-nitropyridine-2,6-dicarboxylic acid;

Chemical Property of 4-Nitro-2,6-pyridinedicarboxylic acid

Chemical Property:

• Boiling Point: 527.7 °C at 760 mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 272.9 °C
• PSA: 133.31000
• Density: 1.774 g/cm³
• LogP: 0.90940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Nitropyridine-2,6-dicarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitro-2,6-pyridinedicarboxylic acid

There total 9 articles about 4-Nitro-2,6-pyridinedicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-nitro-2,6-dimethylpyridine (4913-57-9) → 4-nitro-pyridine-2,6-dicarboxylic acid (63897-10-9)

Guidance literature:

With potassium permanganate; Inert atmosphere;

DOI:10.1007/s10562-010-0433-x

Reference yield:

chelidamic acid (138-60-3) → 4-nitro-pyridine-2,6-dicarboxylic acid (63897-10-9)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅ / CHCl₃ / 72 h / Heating

2: water

3: aq. ammonia / 24 h / 150 °C / bomb

4: 30percent H₂O₂, fuming H₂SO₄ / 1.) 10 deg C, several hours, 2.) room temperature, 2 d

With ammonium hydroxide; phosphorus pentachloride; sulfuric acid; water; dihydrogen peroxide; In chloroform;

DOI:10.1021/ja00522a004

Reference yield:

4-amino-2,6-pyridinedicarboxylic acid (2683-49-0) → 4-nitro-pyridine-2,6-dicarboxylic acid (63897-10-9)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; Yield given; 1.) 10 deg C, several hours, 2.) room temperature, 2 d;

DOI:10.1021/ja00522a004

upstream raw materials:

4-amino-2,6-pyridinedicarboxylic acid

4-chloropyridine-2,6-dicarbonyl dichloride

4-chloro-2,6-pyridinedicarboxylic acid

chelidamic acid

Downstream raw materials:

4-nitro-2,6-diacetylpyridine bis(2,4,6-trimethylphenylimine)

C₁₅H₁₈ClNO₇*C₈H₁₁N*ClHO₄

C₁₅H₁₈ClNO₇*C₇H₉N*ClHO₄

C₁₅H₁₈ClNO₇*C₇H₉N*CHNS

Refernces

• 1、 Bradshaw, J. S.,Maas, G. E.,Lamb, J. D.,Izatt, R. M.,Christensen J. J.. "Cation Complexing Properties of Synthetic Macrocyclic Polyether-Diester Ligands Containing the Pyridine Subcyclic Unit". . p. 467 - 474. Retrieved 2007/10/02.