C₁₈H₂₄O₄

Base Information

• Chemical Name: C₁₈H₂₄O₄
• CAS No.: 1222085-73-5
• Molecular Formula: C₁₈H₂₄O₄
• Molecular Weight: 304.386
• Mol file: 1222085-73-5.mol

Synonyms:

Chemical Property of C₁₈H₂₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₄O₄

There total 3 articles about C₁₈H₂₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-phenylhept-2-en-1-yl acetate (1222085-71-3) + malonic acid dimethyl ester (108-59-8) → C18H24O4 (1222085-73-5) + (E)-dimethyl 2-(1-phenylhept-1-en-3-yl)malonate (1222085-72-4)

Guidance literature:

(E)-1-phenylhept-2-en-1-yl acetate; With palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; at 20 - 40 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200905399

Reference yield:

(1E)-1-phenyl-1-hepten-3-yl acetate (80006-88-8) + malonic acid dimethyl ester (108-59-8) → C18H24O4 (1222085-73-5) + (E)-dimethyl 2-(1-phenylhept-1-en-3-yl)malonate (1222085-72-4)

Guidance literature:

(1E)-1-phenyl-1-hepten-3-yl acetate; With palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; at 20 - 40 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200905399

Reference yield:

(E)-1-phenylhept-2-en-1-yl acetate (1222085-71-3) + sodiodimethylmalonate (18424-76-5) → C18H24O4 (1222085-73-5) + (E)-dimethyl 2-(1-phenylhept-1-en-3-yl)malonate (1222085-72-4)

Guidance literature:

With palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 40 ℃; for 12h; Reagent/catalyst; Temperature; Time; Overall yield = 95 %; regioselective reaction;

DOI:10.1039/c3sc53035c

upstream raw materials:

(E)-1-phenylhept-2-en-1-yl acetate

malonic acid dimethyl ester

(1E)-1-phenyl-1-hepten-3-yl acetate

sodiodimethylmalonate

Refernces

• 1、 Hussain, Mahmud M.,Walsh, Patrick J.. "Allylie substitution versus Suzuki cross-coupling: Capitalizing on chemoselectivity with bifunctional substrates". supporting information; experimental part. p. 1834 - 1837. Retrieved 2010/06/21.