N-Boc-2-azidoethylaMine

Base Information

• Chemical Name: N-Boc-2-azidoethylaMine
• CAS No.: 117861-38-8
• Molecular Formula: C7H14N4O2
• Molecular Weight: 186.214
• Hs Code.: 2929909090
• Mol file: 117861-38-8.mol

Synonyms:N-Boc-2-Azidoethylamine;N-Boc-2-azidoaminoethane;

Chemical Property of N-Boc-2-azidoethylaMine

Chemical Property:

• PSA: 91.57000
• LogP: 1.47856

Purity/Quality:

98%min ^*data from raw suppliers

N-Boc-2-azidoethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-2-azidoethylaMine

There total 11 articles about N-Boc-2-azidoethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(tert-butoxycarbonylamino)ethyl bromide (39684-80-5) → tert-butyl 2-azidoethylcarbamate (117861-38-8)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 110 ℃; for 12h;

DOI:10.1016/j.bmcl.2016.05.078

Reference yield: 98.0%

2-(tert-butoxycarbonylamino)ethyl methanesulfonate (96628-67-0) → tert-butyl 2-azidoethylcarbamate (117861-38-8) + N-(tert-butoxycarbonyl)aziridine (97308-23-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 90 ℃; for 0.0333333h; microwave irradiation;

Reference yield: 90.0%

N-BOC-1,2-diaminoethane (57260-73-8) → tert-butyl 2-azidoethylcarbamate (117861-38-8)

Guidance literature:

With triflic azide; potassium carbonate; copper(II) sulfate; In methanol; water; at 20 ℃;

DOI:10.1039/b609446e

upstream raw materials:

2-(N-tert-butoxycarbonylamino)ethanol

2-(tert-butoxycarbonylamino)ethyl methanesulfonate

N-BOC-1,2-diaminoethane

di-tert-butyl dicarbonate

Downstream raw materials:

N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride

{2-[4-(4-{5-[5-(4-hydroxyphenyl)-3-phenyl-7H-pyrrol-2-ylimino]-4-phenyl-5H-pyrrol-2-yl}-phenoxymethyl)-[l,2,3]triazol-l-yl]ethyl}carbamic acid t-butyl ester, BF₂ chelate

1-amino-2-azidoethane

methyl (S)-2-(3-(2-(tert-butoxycarbonyl)aminoethyl)thioureido)-3-phenylpropanoate

Refernces

• 1、 Ladd, Elizabeth,Sheikhi, Amir,Li, Na,Van De Ven, Theo G.M.,Kakkar, Ashok. "Design and synthesis of dendrimers with facile surface group functionalization, and an evaluation of their bactericidal efficacy". . . Retrieved 2017.
• 2、 Henry, Lucas,Delsuc, Nicolas,Laugel, Cécile,Lambert, Fran?ois,Sandt, Christophe,Hostachy, Sarah,Bernard, Anne-Sophie,Bertrand, Hélène C.,Grimaud, Laurence,Baillet-Guffroy, Arlette,Policar, Clotilde. "Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging". . p. 987 - 991. Retrieved 2018.
• 3、 Clave, Guillaume,Chatelain, Gregory,Filoramo, Arianna,Gasparutto, Didier,Saint-Pierre, Christine,Le Cam, Eric,Pietrement, Olivier,Guerineau, Vincent,Campidelli, Stephane. "Synthesis of a multibranched porphyrin-oligonucleotide scaffold for the construction of DNA-based nano-architectures". . p. 2778 - 2783. Retrieved 2014.
• 4、 Howell, Lesley A.,Howman, Aaron,O'Connell, Maria A.,Mueller, Anja,Searcey, Mark. "Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry". . p. 5880 - 5883. Retrieved 2009.