N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE

Base Information

• Chemical Name: N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE
• CAS No.: 79513-35-2
• Molecular Formula: C₇H₁₆N₂O₂*ClH
• Molecular Weight: 196.677
• Mol file: 79513-35-2.mol

Synonyms:Carbamicacid, (2-aminoethyl)-, 1,1-dimethylethyl ester, monohydrochloride (9CI);N-(tert-Butyloxycarbonyl)-1,2-ethylenediamine hydrochloride;N-tert-Butoxycarbonylethylenediamine hydrochloride;

Chemical Property of N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Melting Point: 148-151 °C
• Boiling Point: 252.8 °C at 760 mmHg
• Flash Point: 106.7 °C
• PSA: 64.35000
• LogP: 2.36300
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-EthylenediamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE is used in the synthesis of Thyronamine derivatives and analogs.

Technology Process of N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE

There total 7 articles about N-BOC-ETHYLENEDIAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-BOC-1,2-diaminoethane (57260-73-8) → N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride (79513-35-2,117083-06-4)

Guidance literature:

With ammonium chloride; In methanol; water; for 0.25h;

DOI:10.1021/acsinfecdis.0c00068

Reference yield: 96.0%

tert-butyl 2-azidoethylcarbamate (117861-38-8) → N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride (79513-35-2,117083-06-4)

Guidance literature:

With chloroform; hydrogen; palladium on activated charcoal; In methanol; for 1h; under 1551.4 Torr;

DOI:10.1055/s-1990-26879

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,2-diaminoethane dihydrochloride (333-18-6) → N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride (79513-35-2,117083-06-4)

Guidance literature:

With sodium hydroxide; In water; isopropyl alcohol; for 24h; Ambient temperature;

upstream raw materials:

di-tert-butyl dicarbonate

1,2-diaminoethane dihydrochloride

tert-butyl 2-azidoethylcarbamate

tert-butyl N-2-[(tert-butoxycarbonyl)amino]ethylcarbamate

Downstream raw materials:

2-amino-ethylguanidine dihydrochloride

tert-butyl (2-acrylamidoethyl)carbamate

1-[(S)-N-Cbz-2-Amino-3-phenylpropanoyl]-4-(t-butoxycarbonyl)-1,4-diazabutane

(S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid

Refernces

• 1、 Spivak, David,Shea, Kenneth J.. "Molecular Imprinting of Carboxylic Acids Employing Novel Functional Macroporous Polymers". . p. 4627 - 4634. Retrieved 2007/10/03.
• 2、 Mattingly, Phillip G.. "Mono-Protected Diamines. Nα-tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides from Amino alcohols.". . p. 366 - 368. Retrieved 2007/10/02.