trans-4-Methylcyclohexanecarboxylic acid

Base Information

• Chemical Name: trans-4-Methylcyclohexanecarboxylic acid
• CAS No.: 13064-83-0
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.198
• Hs Code.: 29162090
• Mol file: 13064-83-0.mol

Synonyms:trans-4-Methylcyclohexane-1-carboxylicacid;

Chemical Property of trans-4-Methylcyclohexanecarboxylic acid

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Melting Point: 109-111 °C(lit.)
• Refractive Index: 1.467
• Boiling Point: 247.467 °C at 760 mmHg
• PKA: pK1:4.89 (25°C)
• Flash Point: 110.727 °C
• PSA: 37.30000
• Density: 1.025 g/cm³
• LogP: 1.89730
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99.9% ^*data from raw suppliers

trans-4-Methylcyclohexanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: trans-4-Methyl-1-cyclohexanecarboxylic acid may be used in chemical synthesis.

Technology Process of trans-4-Methylcyclohexanecarboxylic acid

There total 18 articles about trans-4-Methylcyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

→ 4-methylcyclohexanecarboxylic acid (4331-54-8) + trans-4-methylcyclohexanecarboxylic acid (934-67-8,4331-54-8,13064-83-0)

Guidance literature:

Reference yield: 90.0%

p-Toluic acid (99-94-5) → trans-4-methylcyclohexanecarboxylic acid (934-67-8,4331-54-8,13064-83-0) + (cis)-4-methylcyclohexanecarboxylic acid (934-67-8)

Guidance literature:

p-Toluic acid; With sodium hydroxide; hydrogen; In water; at 140 - 150 ℃; for 1h; under 22502.3 - 30003 Torr;

With sodium hydroxide; In water; at 260 - 280 ℃; for 2h; under 22502.3 - 30003 Torr; Further stages.;

DOI:10.1016/j.tetlet.2004.06.117

Reference yield:

p-Toluic acid (99-94-5) → trans-4-methylcyclohexanecarboxylic acid (934-67-8,4331-54-8,13064-83-0)

Guidance literature:

With sodium hydroxide; nickel; at 200 ℃; under 110326 - 147102 Torr; Hydrogenation;

DOI:10.1039/jr9390001245

upstream raw materials:

4-acetyl-1-methylcyclohexane

(cis)-4-methylcyclohexanecarboxylic acid

p-Toluic acid

p-methylcyclohexanol

Downstream raw materials:

4-methyl-1-cyclohexanecarboxylic acid methyl ester

trans-4-methylcyclohexanecarbonyl chloride

4-methylcyclohexene

trans-4-methylcyclohexan-1-ol

Refernces

• 1、 Kwart,Scalzi. "". . p. 5496,5497. Retrieved 1964.
• 2、 Jiang, Hezhan,Yu, Xiaolong,Nie, Renfeng,Lu, Xinhuan,Zhou, Dan,Xia, Qinghua. "Selective hydrogenation of aromatic carboxylic acids over basic N-doped mesoporous carbon supported palladium catalysts". . p. 73 - 81. Retrieved 2016/05/02.
• 3、 Bazurin, Alexey A.,Krasnikov, Sergey V.,Obuchova, Tatiana A.,Danilova, Angelina S.,Balakin, Konstantin V.. "Improved synthesis of trans-4-alkylcyclohexane carboxylic acids". . p. 6669 - 6672. Retrieved 2007/10/03.