GALANGIN-3-METHYLETHER

Base Information

• Chemical Name: GALANGIN-3-METHYLETHER
• CAS No.: 6665-74-3
• Molecular Formula: C16H12 O5
• Molecular Weight: 284.268
• Hs Code.: 2914509090
• Mol file: 6665-74-3.mol

Synonyms:Flavone,5,7-dihydroxy-3-methoxy- (7CI,8CI); 3-Methylgalangin; 3-O-Methylgalangin;5,7-Dihydroxy-3-methoxyflavone; Galangin 3-O-methyl ether; Galangin 3-methylether

Chemical Property of GALANGIN-3-METHYLETHER

Chemical Property:

• Vapor Pressure: 1.06E-11mmHg at 25°C
• Melting Point: 299 °C
• Boiling Point: 526.4°C at 760 mmHg
• PKA: 6.32±0.40(Predicted)
• Flash Point: 201.5°C
• PSA: 79.90000
• Density: 1.47g/cm³
• LogP: 2.87980

Purity/Quality:

99%, ^*data from raw suppliers

3-O-Methylgalangin 99.54% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GALANGIN-3-METHYLETHER

There total 9 articles about GALANGIN-3-METHYLETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7) + benzoic acid anhydride (93-97-0) → 5,7-dihydroxy-3-methoxyflavone (6665-74-3)

Guidance literature:

With sodium benzoate; at 180 ℃; Kochen des Reaktionsprodukts mit waessrig-alkoholischer Natronlauge;

Reference yield:

5-hydroxy-3-methoxy-7-tosyloxyflavone (17892-78-3) → 5,7-dihydroxy-3-methoxyflavone (6665-74-3)

Guidance literature:

With sodium hydroxide; In acetone; for 2h; Heating;

Reference yield:

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone (55317-02-7) + 3,4-bis-benzoyloxy-benzoic acid-anhydride (854693-27-9) → 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-methoxy-chromen-4-on (1486-70-0) + 5,7-dihydroxy-3-methoxyflavone (6665-74-3)

Guidance literature:

With triethylamine; at 165 ℃; Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge;

upstream raw materials:

2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone

3,4-bis-benzoyloxy-benzoic acid-anhydride

galangin

dimethyl sulfate

Downstream raw materials:

3,5-dihydroxyphenol

benzoic acid

oxalic acid

3,5,7,8-tetrahydroxyflavone

Refernces

• 1、 Dwivedi, P.,Kapoor, N. K.,Khanna, R. N.. "Synthesis of Platanetin - A Naturally Occuring Prenylated Flavone". . p. 77 - 78. Retrieved 2007/10/02.