N-(2-PHENYLETHYL)-PHENYLACETAMIDE

Base Information

• Chemical Name: N-(2-PHENYLETHYL)-PHENYLACETAMIDE
• CAS No.: 5460-60-6
• Molecular Formula: C16H17 N O
• Molecular Weight: 239.317
• Hs Code.: 2924299090
• Mol file: 5460-60-6.mol

Synonyms:Acetamide,N-phenethyl-2-phenyl- (6CI,7CI,8CI); 2-Phenyl-N-(2-phenylethyl)acetamide;N-(2-Phenylethyl)phenylacetamide; N-Phenethyl-2-phenylacetamide; NSC 23033; NSC43754

Chemical Property of N-(2-PHENYLETHYL)-PHENYLACETAMIDE

Chemical Property:

• Vapor Pressure: 1.43E-08mmHg at 25°C
• Boiling Point: 457.9°C at 760 mmHg
• Flash Point: 276.6°C
• PSA: 29.10000
• Density: 1.078g/cm³
• LogP: 2.97890
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Phenethyl-2-phenyl-acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-(2-PHENYLETHYL)-PHENYLACETAMIDE

There total 40 articles about N-(2-PHENYLETHYL)-PHENYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylacetic acid (103-82-2) + phenethylamine (64-04-0) → N-phenethyl-2-phenylacetamide (5460-60-6)

Guidance literature:

In neat (no solvent); at 150 ℃; for 0.5h; Temperature; Time; Microwave irradiation;

DOI:10.1080/00397911.2011.642925

Reference yield: 98.0%

2-phenylethylamine hydrochloride (156-28-5) + phenylacetylene (536-74-3) → N-phenethyl-2-phenylacetamide (5460-60-6)

Guidance literature:

With potassium hexafluorophosphate; 4-methylpyridine-1-oxide; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); potassium carbonate; In 1,2-dichloro-ethane; at 100 ℃; for 24h; Reagent/catalyst; Catalytic behavior; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b01993

Reference yield: 96.0%

2-oxo-3-(phenyl)propionic acid (156-06-9) + O-benzoyl-N-phenethylhydroxylamine (69424-54-0) → N-phenethyl-2-phenylacetamide (5460-60-6)

Guidance literature:

In water; tert-butyl alcohol; at 40 ℃; for 15h;

DOI:10.1021/jo800223j

upstream raw materials:

bis-phenylacetyl-amine

phenylacetic acid

phenethylamine

Ethyl 2-phenylethanoate

Downstream raw materials:

1-benzoylisoquinoline

1-benzyl-2-methyl-1,2,3,4-tetrahydroisoquinoline

1-phenylmethy-3,4-dihydro-1H-isoquinoline-2-carboxaldehyde

diphenethylamine

Refernces

• 1、 Wang, Jian,Zhang, Ru-Yan,Wang, Ya-Cong,Chen, Xiang-Zhao,Yin, Xu-Guang,Du, Jing-Jing,Lei, Ze,Xin, Ling-Ming,Gao, Xiao-Fei,Liu, Zheng,Guo, Jun. "Polyfluorophenyl Ester-Terminated Homobifunctional Cross-Linkers for Protein Conjugation". . p. 1934 - 1938. Retrieved 2017.
• 2、 Sole, Roberto,Agostinis, Lodovico,Conca, Silvia,Gatto, Vanessa,Bardella, Noemi,Morandini, Andrea,Buranello, Chiara,Beghetto, Valentina. "Synthesis of Amidation Agents and Their Reactivity in Condensation Reactions". supporting information. p. 1672 - 1682. Retrieved 2021/02/01.
• 3、 Wang, Hui,Dong, Wei,Hou, Zhipeng,Cheng, Lidan,Li, Xiufen,Huang, Longjiang. "Direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2". . . Retrieved 2020/02/15.