2-Decyn-1-ol

Base Information

• Chemical Name: 2-Decyn-1-ol
• CAS No.: 4117-14-0
• Molecular Formula: C10H18O
• Molecular Weight: 154.252
• Hs Code.: 29052900
• Mol file: 4117-14-0.mol

Synonyms:N-heptylhydroxymethylacetylene;Dec-2-yn-1-ol;

Chemical Property of 2-Decyn-1-ol

Chemical Property:

• Vapor Pressure: 0.482mmHg at 25°C
• Melting Point: 1.9°C (estimate)
• Refractive Index: 1.4585
• Boiling Point: 170.057 °C at 760 mmHg
• PKA: 13.01±0.10(Predicted)
• Flash Point: 58.408 °C
• Density: 0.884 g/cm³
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

2-Decyn-1-ol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Decyn-1-ol is used in the synthesis of antitumor agents, isomers of Panaxytriol and Falcarinol (F101100). Also used in the synthesis of aromatase inhibitors used in the treatment of cancers, primari ly breast and ovarian. 2-Decyn-1-ol is used in the synthesis of antitumor agents, isomers of Panaxytriol and Falcarinol (F101100). Also used in the synthesis of aromatase inhibitors used in the treatment of cancers, primarily breast and ovarian.

Technology Process of 2-Decyn-1-ol

There total 10 articles about 2-Decyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-Bromoheptane (629-04-9) + propargyl alcohol (107-19-7) → 2-decyn-1-ol (4117-14-0)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jo802209m

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-nonyne (3452-09-3) → 2-decyn-1-ol (4117-14-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - -20 ℃;

DOI:10.1016/j.tetlet.2004.07.153

Reference yield:

dec-5-yn-1-ol (68274-97-5) → 3-decyn-1-ol (51721-39-2) + 2-decyn-1-ol (4117-14-0) + 4-decyne-1-ol (69222-06-6) + dec-6-yn-1-ol (69222-07-7) + 7-decyn-1-ol (69222-08-8) + 9-decyn-1-ol (17643-36-6)

Guidance literature:

With sodium 1,3-diaminopropane; In various solvent(s); at 50 ℃; for 4h; Product distribution; other times and temperature;

upstream raw materials:

1-Bromoheptane

3-(tetrahydropyran-2'-yloxy)propyne

formaldehyd

1-nonyne

Downstream raw materials:

C₂₀H₃₆O

C₂₀H₂₈O

Refernces

• 1、 Steib, Philip,Breit, Bernhard. "Enantioselective Rhodium-Catalyzed Dimerization of ω-Allenyl Carboxylic Acids: Straightforward Synthesis of C2-Symmetric Macrodiolides". supporting information. p. 6572 - 6576. Retrieved 2018/05/08.
• 2、 Mao, Jianyou,Li, Shuoning,Zhong, Jiangchun,Wang, Bo,Jin, Jing,Gao, Zidong,Yang, Hanze,Bian, Qinghua. "Total synthesis of panaxydol and its stereoisomers as potential anticancer agents". . p. 69 - 77. Retrieved 2015/12/31.