Benzonitrile, 4-azido-

Base Information

• Chemical Name: Benzonitrile, 4-azido-
• CAS No.: 18523-41-6
• Molecular Formula: C7H4N4
• Molecular Weight: 144.136
• Mol file: 18523-41-6.mol

Synonyms:

Chemical Property of Benzonitrile, 4-azido-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzonitrile, 4-azido-

There total 21 articles about Benzonitrile, 4-azido- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-cyanophenyldiazonium tetrafluoroborate (2252-32-6) → 4-azidobenzonitrile (18523-41-6)

Guidance literature:

With hydroxylamine hydrochloride; In water; at 20 ℃; for 24h; Green chemistry;

DOI:10.1039/c6gc02379g

Reference yield: 98.0%

4-Aminobenzonitrile (873-74-5) → 4-azidobenzonitrile (18523-41-6)

Guidance literature:

With tert.-butylnitrite; trimethylsilylazide; trifluoroacetic acid; In acetonitrile; at 0 - 20 ℃;

Reference yield: 98.0%

4-cyanophenylboronic acid (126747-14-6) → 4-azidobenzonitrile (18523-41-6)

Guidance literature:

With sodium azide; copper diacetate; In methanol; at 55 ℃; for 3h;

DOI:10.1055/s-0029-1218683

upstream raw materials:

pyridine

p-toluenesulfonyl chloride

4-Aminobenzonitrile

4-Pentazol-1-yl-benzonitrile

Downstream raw materials:

N-(4-cyanophenyl)(triphenyl) iminophosphorane

Dimethyldisulphide

4-amino-3-[(methylthio)methyl]benzonitrile

4-Aminobenzonitrile

Refernces

• 1、 Zhang, Yi,Zhang, Ting-jian,Li, Xin-yang,Liang, Jing-wei,Tu, Shun,Xu, Hai-li,Xue, Wen-han,Qian, Xin-hua,Zhang, Zhen-hao,Zhang, Xu,Meng, Fan-hao. "2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents". . . Retrieved 2021.
• 2、 Proietti, Giampiero,Prathap, Kaniraj Jeya,Ye, Xinchen,Olsson, Richard T.,Dinér, Peter. "Nickel Boride Catalyzed Reductions of Nitro Compounds and Azides: Nanocellulose-Supported Catalysts in Tandem Reactions". supporting information. p. 133 - 146. Retrieved 2021/11/04.