5,6-DIPHENYLPYRAZIN-2-OL

Base Information

• Chemical Name: 5,6-DIPHENYLPYRAZIN-2-OL
• CAS No.: 18591-57-6
• Molecular Formula: C16H12N2O
• Molecular Weight: 248.284
• Mol file: 18591-57-6.mol

Synonyms:5,6-diphenylpyrazin-2-ol;5,6-Diphenyl-1H-pyrazin-2-on;5,6-diphenylpyrazin-2-(1H)-one;5,6-Diphenyl-2-pyrazinol;1.2-Dihydro-2-oxo-3.5-diphenylpyrazin;5,6-diphenyl-2(1H)-pyrazinone;2,3-Diphenyl-6-hydroxypyrazine;5.6-Diphenyl-pyrazin-2-on;

Chemical Property of 5,6-DIPHENYLPYRAZIN-2-OL

Chemical Property:

• Vapor Pressure: 2.61E-10mmHg at 25°C
• Melting Point: 225-227 °C
• Boiling Point: 492.2oC at 760 mmHg
• PKA: 10.55±0.60(Predicted)
• Flash Point: 251.4oC
• PSA: 45.75000
• Density: 1.17g/cm3
• LogP: 3.10390
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

HPLC>99% ^*data from raw suppliers

5,6-Diphenylpyrazinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6-Diphenylpyrazinol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

Technology Process of 5,6-DIPHENYLPYRAZIN-2-OL

There total 26 articles about 5,6-DIPHENYLPYRAZIN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

glycinamide hydrochloride (1668-10-6) + benzil (134-81-6) → 5,6-diphenyl-2-hydroxypyrazine (18591-57-6)

Guidance literature:

glycinamide hydrochloride; benzil; With sodium hydroxide; In methanol; Reflux; Inert atmosphere;

With hydrogenchloride; In methanol; water; at 0 - 25 ℃; for 0.5h; Reagent/catalyst; Solvent;

Reference yield: 90.0%

glycine ethyl ester hydrochloride (623-33-6) + 2,3-diphenyl-2H-azirine (16483-98-0) → 2,3-Diphenyl-6-hydroxypyrazine (18591-57-6)

Guidance literature:

With oxygen; triethylamine; In acetonitrile; at 80 ℃; for 48h;

DOI:10.1016/S0040-4039(00)86390-X

Reference yield: 89.0%

5-Acetoxy-2,3-diphenylpyrazine (83520-60-9) → 2,3-Diphenyl-6-hydroxypyrazine (18591-57-6)

Guidance literature:

With sodium hydroxide; In methanol; for 1h; Heating;

upstream raw materials:

3-oxo-5,6-diphenyl-3,4-dihydro-pyrazine-2-carboxylic acid

2-aminoacetonitrile hydrochloride

benzil

H-Gly-NH₂

Downstream raw materials:

3,5,6-triphenylpyrazin-2-(1H)-one

5,6-diphenyl-1H-pyrazine-2-thione

2-chloro-5,6-diphenylpyrazine

2-bromo-5,6-diphenylpyrazine

Refernces

• 1、 Ghosh, Prithwish,Kwon, Na Yeon,Kim, Saegun,Han, Sangil,Lee, Suk Hun,An, Won,Mishra, Neeraj Kumar,Han, Soo Bong,Kim, In Su. "C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**". supporting information. p. 191 - 196. Retrieved 2020/10/29.
• 2、 -. "A preparation method of a diphenyl pyrazine compound". Paragraph 0049-0051; 0069-0072; 0089-0091; 0108-0110; 0127. . Retrieved 2018/10/27.