Begin by studying the molecular structure of podophyllotoxin and identifying key functional groups responsible for its antitumor activity. Consider introducing nitrogen atoms (aza-substitution) in the molecule while retaining the crucial structural elements.
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2-aza-4'-demethyldeoxypodophyllotoxin
2-amino-4-ethoxy-5-methoxybenzonitrile
(2R,3S,4R,5R)-5-((benzoyloxy)methyl)-3-chlorotetrahydrofuran-2,4-diyl dibenzoate
N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)propionamide
7-deoxy-7-α-azido-paclitaxel
