The Dts group is typically introduced to the thiol group of a cysteine residue through a reaction with a reagent such as Dts-Cl (Dithiasuccinoyl chloride) or Dts-NHS (Dithiasuccinoyl N-hydroxysuccinimide). This reaction results in the formation of a Dts-protected cysteine residue, where the thiol group is capped with the Dts moiety.
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