- Trimethylcolchicinic acid
- Trimethylcolchicinic acid methyl ether
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Cas Database |
| Name |
Trimethylcolchicinic acid methyl ether |
EINECS | N/A |
| CAS No. | 3476-50-4 | Density | 1.25g/cm3 |
| PSA | 80.01000 | LogP | 3.39450 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C20H23 N O5 | Boiling Point | 626.6°Cat760mmHg |
| Molecular Weight | 357.406 | Flash Point | 287°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and intramuscular routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE and ETHERS. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)-; Colchicine, N-deacetyl-(7CI,8CI); Colchicine, deacetyl- (6CI); (-)-7-Deacetylcolchicine;(-)-Deacetylcolchicine; Deacetylcolchicine; Desacetylcolchicine;N-Deacetylcolchicine; N-Desacetylcolchicine; NSC 201400 |
Article Data | 2 |
Trimethylcolchicinic acid methyl ether Chemical Properties
IUPAC Name: (7S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
Molecular Formula: C20H23NO5
Molecular Weight: 357.44g/mol
Density: 1.25g/cm3
Boiling Point: 626.6°C at 760mmHg
Flash Point: 287°C
Freely Rotating Bonds: 5
Polar Surface Area: 57.23 Å2
Index of Refraction: 1.597
Molar Refractivity: 97.19 cm3
Molar Volume: 284.9 cm3
Polarizability: 38.53 ×10-24 cm3
Surface Tension: 51.7 dyne/cm
Enthalpy of Vaporization: 92.74 kJ/mol
Vapour Pressure: 1.29E-15 mmHg at 25°C
The Cas Register Number of Trimethylcolchicinic acid methyl ether is 3476-50-4.The chemical synonyms of Trimethylcolchicinic acid methyl ether (CAS NO.3476-50-4) are (7S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one ; Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)- ; (S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one ; 7-Amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one ; Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)- (9CI) ; Colchicine analog ; Colchicine, N-deacetyl- ; Colchinic acid trimethyl ; Deacetylcolchicine ; N-Deacetylcolchicine ; Tmca methyl ether ; Trimethylcolchicinic acid methyl ether .The molecular structure of Trimethylcolchicinic acid methyl ether (CAS NO.3476-50-4) is
.
Trimethylcolchicinic acid methyl ether Uses
Trimethylcolchicinic acid methyl ether (CAS NO.3476-50-4) is used as organic intermediate.
Trimethylcolchicinic acid methyl ether Toxicity Data With Reference
| 1. | oms-mus-par 46 mg/kg | CANCAR Cancer. 3 (1950),134. | ||
| 2. | spm-mus-par 46 mg/kg | CANCAR Cancer. 3 (1950),134. | ||
| 3. | ipr-mus LD50:46 mg/kg | MDREP* U.S. Army, Chemical Corps Medical Division Reports .(Army Chemical Center, MD.: )1949,204. | ||
| 4. | ims-mus LD50:49 mg/kg | JMCMAR Journal of Medicinal Chemistry. 24 (1981),257. |
Trimethylcolchicinic acid methyl ether Safety Profile
Poison by intraperitoneal and intramuscular routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE and ETHERS.
Safety Statements: 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 3
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