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CAS No.: | 111991-20-9 |
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Name: | 2-(2,4,5-trifluorophenyl)acetaldehyde |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C8H5 F3 O |
Molecular Weight: | 174.122 |
Synonyms: | 2-(2,4,5-trifluorophenyl)acetaldehyde |
Density: | 1.317±0.06 g/cm3(Predicted) |
Boiling Point: | 196.8±35.0 °C(Predicted) |
PSA: | 17.07000 |
LogP: | 1.84530 |
2-(2,4,5-trifluorophenyl)ethanol
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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With manganese(IV) oxide In toluene for 8h; Reagent/catalyst; Solvent; Reflux; | 75% |
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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With hydrogenchloride In 1,4-dioxane at 20℃; for 6h; | |
With hydrogenchloride In tetrahydrofuran; water at 0 - 30℃; for 2h; | 2 g |
With hydrogenchloride In 1,4-dioxane at 20℃; for 6h; |
2,4,5-trifluorobenzaldehyde
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C 1.2: 48 h / 20 °C 2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 0 - 30 °C View Scheme |
(2,4,5-trifluorophenyl)acetic acid
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: sulfuric acid / methanol / 3 h / Heating 1.2: 20 °C / Cooling with ice 2.1: manganese(IV) oxide / toluene / 8 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: sulfuric acid / 3 h / Reflux 2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h 2.2: 5 h View Scheme |
2,4,5-trifluorophenylacetic acid methyl ester
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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Stage #1: 2,4,5-trifluorophenylacetic acid methyl ester With sodium tetrahydroborate In tetrahydrofuran for 1h; Stage #2: With pyridinium chlorochromate In dichloromethane for 5h; |
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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With hydrogenchloride; Aliquat 336 In water; acetone at 25 - 30℃; for 24h; Reagent/catalyst; |
2,4,5-trifluoroaniline
2-(2,4,5-trifluorophenyl)acetaldehyde
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: hydrogenchloride / water / 1 h 1.2: 0 °C 1.3: 0 °C 2.1: Aliquat 336; hydrogenchloride / water; acetone / 24 h / 25 - 30 °C View Scheme |
2-(2,4,5-trifluorophenyl)acetaldehyde
(R)-2-methylpropane-2-sulfinamide
Conditions | Yield |
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With pyridinium p-toluenesulfonate; sodium sulfate In dichloromethane at 20℃; for 16h; | 96% |
Conditions | Yield |
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With piperidine In toluene Temperature; Solvent; Reagent/catalyst; Knoevenagel Condensation; Reflux; | 94.3% |
2-(2,4,5-trifluorophenyl)acetaldehyde
L-Phenylalaninol
allyltributylstanane
Conditions | Yield |
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Stage #1: 2-(2,4,5-trifluorophenyl)acetaldehyde; L-Phenylalaninol With magnesium(I) iodide In dichloromethane at 20℃; for 0.166667h; Inert atmosphere; Stage #2: allyltributylstanane In dichloromethane at 20℃; Reagent/catalyst; Solvent; Inert atmosphere; | 82% |