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CAS No.: | 25637-18-7 |
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Name: | 4-IODOTETRAHYDRO-2H-PYRAN |
Article Data: | 14 |
Molecular Structure: | |
Formula: | C5H9IO |
Molecular Weight: | 212.03 |
Synonyms: | 4-Iodooxacyclohexane; |
Density: | 1.777 g/cm3 |
Boiling Point: | 208.154 °C at 760 mmHg |
Flash Point: | 79.689 °C |
Hazard Symbols: | Xi |
Risk Codes: | 36-36/37/38 |
Safety: | 26-36/37/39 |
PSA: | 9.23000 |
LogP: | 1.60040 |
Tetrahydro-pyran-4-ol
4-iodotetrahydropyran
Conditions | Yield |
---|---|
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 16h; Cooling with ice; Inert atmosphere; | 65% |
With 1H-imidazole; iodine; triphenylphosphine In tetrahydrofuran at 0 - 20℃; | 64.3% |
Stage #1: Tetrahydro-pyran-4-ol With 1H-imidazole; triphenylphosphine In dichloromethane for 0.25h; Inert atmosphere; Stage #2: With iodine In dichloromethane for 16h; Inert atmosphere; | 51% |
toluene-4-sulfonic acid tetrahydropyran-4-yl ester
4-iodotetrahydropyran
Conditions | Yield |
---|---|
With acetone; sodium iodide |
4-pyrone
4-iodotetrahydropyran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Raney nickel / Hydrogenation 2: pyridine 3: acetone; sodium iodide View Scheme |
4-iodotetrahydropyran
tert-butylisonitrile
Conditions | Yield |
---|---|
Stage #1: 4-iodotetrahydropyran; tert-butylisonitrile With bis(1,5-cyclooctadiene)nickel (0); water; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride; sodium t-butanolate In tert-butyl alcohol at 100℃; for 12h; Inert atmosphere; Stage #2: With hydrogenchloride In tert-butyl alcohol at 20℃; for 0.0833333h; Inert atmosphere; | 98% |
4-iodotetrahydropyran
((triisopropylsilyl)ethynyl)magnesium bromide
Conditions | Yield |
---|---|
With iron(II) bromide In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20℃; for 16h; Inert atmosphere; Glovebox; | 96% |
4-iodotetrahydropyran
tert-butyl pyrrolidine-1-carboxylate
(R)-tert-butyl 2-(tetrahydro-2H-pyran-4-yl)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl pyrrolidine-1-carboxylate With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium In diethyl ether; cyclohexane at -78℃; for 3.5h; Inert atmosphere; Stage #2: With zinc(II) iodide In tetrahydrofuran; diethyl ether; cyclohexane at -78 - 20℃; for 1.5h; Cooling with acetone-dry ice; Inert atmosphere; Stage #3: 4-iodotetrahydropyran With (1,2-dimethoxyethane)dichloronickel(II); (1S,2S)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine In tetrahydrofuran; diethyl ether; cyclohexane at 20℃; for 60h; Reagent/catalyst; Negishi Coupling; Inert atmosphere; enantioselective reaction; | 94% |
Conditions | Yield |
---|---|
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); potassium methanolate In tetrahydrofuran at 20℃; under 4560.31 Torr; for 15h; | 94% |
Conditions | Yield |
---|---|
With (1,2-dimethoxyethane)dichloronickel(II); 1,5-bis-(diphenylphosphino)pentane; C17H20N2O In tetrahydrofuran at 5℃; stereoselective reaction; | 91% |
4-iodotetrahydropyran
3-bromo-2-phenyl-1,2-dihydrobenzo[e][1,2]azaborinine
2-phenyl-3-(4-tetrahydro-2H-pyranyl)-2,1-borazaronaphthalene
Conditions | Yield |
---|---|
With 4-Ethylpyridine; manganese; sodium tetrafluoroborate; 4,4'-dimethyl-2,2'-bipyridines; (1,2-dimethoxyethane)dichloronickel(II) In N,N-dimethyl acetamide; cyclohexane at 40℃; for 18h; Inert atmosphere; Sealed tube; | 90% |
4-iodotetrahydropyran
5-hexynonitrile
Conditions | Yield |
---|---|
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); (tpy')NiI; lithium isopropoxide; HSiPh3 In 1,2-dimethoxyethane at 25℃; for 2h; Inert atmosphere; diastereoselective reaction; | 90% |
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Molecular Structure:
Molecular Formula: C5H9IO
Molecular Weight: 212.0288
IUPAC Name: 4-Iodooxane
Synonyms of 4-Iodotetrahydro-2H-pyran (CAS NO.25637-18-7): 4-Iodo-tetrahydro-pyran ; 4-Iodotetrahydro-2H-pyran 97%
CAS NO: 25637-18-7
Index of Refraction: 1.546
Molar Refractivity: 37.795 cm3
Molar Volume: 119.328 cm3
Surface Tension: 37.18 dyne/cm
Density: 1.777 g/cm3
Flash Point: 79.689 °C
Enthalpy of Vaporization: 42.628 kJ/mol
Boiling Point: 208.154 °C at 760 mmHg
Vapour Pressure of 4-Iodotetrahydro-2H-pyran (CAS NO.25637-18-7): 0.313 mmHg at 25°C
Hazard Codes of 4-Iodotetrahydro-2H-pyran (CAS NO.25637-18-7): Xi
Hazard Note: Irritant