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26159-34-2

Basic Information
CAS No.: 26159-34-2
Name: Naproxen sodium
Article Data: 7
Molecular Structure:
Molecular Structure of 26159-34-2 (Naproxen sodium)
Formula: C14H13O3.Na
Molecular Weight: 252.245
Synonyms: 2-Naphthaleneaceticacid, 6-methoxy-a-methyl-, sodiumsalt, (S)-;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, L-(-)- (8CI);(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Agilxen;Aleve;Anaprox;Anaprox DS;Apranax;Apraxin;Dafloxen;Duk-F;Flanax;Flanax Forte;Gynestrel;Lefaine;Licorax;Miranax;Naprelan;Naprogesic;
EINECS: 247-486-2
Density: ==
Melting Point: 250-251 °C
Boiling Point: 403.9 °C at 760 mmHg
Flash Point: 154.5 °C
Solubility: Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
Appearance: white powder
Hazard Symbols: HarmfulXn
Risk Codes: 22
Safety: 53-45
PSA: 49.36000
LogP: 1.70180
Synthetic route
racemic 2-(6-methoxy-2-naphthyl)propionic acid

racemic 2-(6-methoxy-2-naphthyl)propionic acid

23981-80-8

naproxen

26159-34-2

Naprelan

Conditions
ConditionsYield
With sodium hydroxide In water; toluene
23981-80-8

naproxen

26159-34-2

Naprelan

Conditions
ConditionsYield
With sodium hydroxide In toluene
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

26159-34-2

Naprelan

Conditions
ConditionsYield
In methanol
With sodium hydroxide In methanol
With sodium hydroxide In methanol at 55℃; Industry scale;
With sodium hydroxide In water Schlenk technique; Inert atmosphere;

C14H13O3(1-)*C56H98O35*Na(1+)

A

51166-71-3

heptakis(2,6-di-O-methyl)cyclomaltoheptaose

B

26159-34-2

Naprelan

Conditions
ConditionsYield
With pluronic copolymer F127 In water at 25℃; Equilibrium constant; Reagent/catalyst;
26159-34-2

Naprelan

22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20℃;98%
With hydrogenchloride In water pH=< 2; Inert atmosphere;94.3%
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

26159-34-2

Naprelan

[Ru(η6-p-cymene)(naproxenate)Cl]

Conditions
ConditionsYield
In methanol at 20℃; for 1h; Schlenk technique; Inert atmosphere;87%
In methanol at 20℃; for 4h;78%
345911-20-8, 19542-80-4, 158060-65-2, 34795-02-3, 15746-57-3

cis-dichlorobis(2,2′-bipyridine)ruthenium(II)

ammonium hexafluorophosphate

26159-34-2

Naprelan

[Ru(2,2'-bipyridine)2(naproxen)][hexafluorophosphate]

Conditions
ConditionsYield
Stage #1: Naprelan With triethylamine In ethanol at 24.84℃;
Stage #2: cis-dichlorobis(2,2′-bipyridine)ruthenium(II) In ethanol for 8h; Reflux;
Stage #3: ammonium hexafluorophosphate In ethanol
66%

[Ru(1,10-phenanthroline)2Cl2]

ammonium hexafluorophosphate

26159-34-2

Naprelan

[Ru(1,10-phenanthroline)2(naproxen)][hexafluorophosphate]

Conditions
ConditionsYield
Stage #1: Naprelan With triethylamine In ethanol at 24.84℃;
Stage #2: [Ru(1,10-phenanthroline)2Cl2] In ethanol for 8h; Reflux;
Stage #3: ammonium hexafluorophosphate In ethanol
61%
7173-51-5

didecyldimethylammonium chloride

26159-34-2

Naprelan

934544-44-2

didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate

Conditions
ConditionsYield
In water at 20℃; for 1h;95%
26159-34-2

Naprelan

7646-85-7

zinc(II) chloride

[Zn2(nap)4]

Conditions
ConditionsYield
In water at 20℃;86%
Downstream Products
163133-43-5
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Specification

The Naproxen sodium, with the CAS registry number 26159-34-2, is also known as 2-Naphthaleneacetic acid,6-methoxy-alpha-methyl-,sodium salt,(S)-. It belongs to the product categories of Essential Chemicals;Reagent Grade;Routine Reagents.Its EINECS number is 247-486-2. This chemical's molecular formula is C14H13NaO3 and molecular weight is 252.24.What's more,Its systematic name is Sodium (-)-2-(6-methoxy-2-naphthyl)propionate.It is an anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Physical properties about Midazolam are:
(1)ACD/LogP:  2.998; (2)# of Rule of 5 Violations:  0; (3)#H bond acceptors:  3; (4)#H bond donors:  1; (5)#Freely Rotating Bonds:  3; (6)Flash Point:  154.5 °C; (7)Enthalpy of Vaporization:  69.1 kJ/mol; (8)Boiling Point:  403.9 °C at 760 mmHg; (9)Vapour Pressure:  3.01E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)[C@H](c1ccc2c(c1)ccc(OC)c2)C;
(2)Std. InChI:InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1;
(3)Std. InChIKey:CDBRNDSHEYLDJV-FVGYRXGTSA-M.

The toxicity data of Midazolam as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 600mg/kg/30D- (600mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988.