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| CAS No.: | 6310-09-4 |
|---|---|
| Name: | 2-ACETYL-5-CHLOROTHIOPHENE |
| Article Data: | 18 |
| Molecular Structure: | |
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|
|
| Formula: | C6H5 Cl O S |
| Molecular Weight: | 160.624 |
| Synonyms: | Ketone,5-chloro-2-thienyl methyl (6CI,7CI,8CI);1-(5-Chloro-2-thienyl)ethanone;1-(5-Chlorothiophen-2-yl)ethanone;2-Acetyl-5-chlorothiophene;2-Chloro-5-acetylthiophene;5-Chloro-2-acetylthiophene;NSC 43020; |
| EINECS: | 228-630-3 |
| Density: | 1.312g/cm3 |
| Melting Point: |
46-49 °C(lit.) |
| Boiling Point: |
117-118 °C17 mm Hg(lit.) |
| Flash Point: | 227 °F |
| Appearance: | white to light yellow crystal powder |
| Risk Codes: | 20/21/22 |
| Safety: | Experimental reproductive effects. A flammable liquid. When heated to decomposition it emits toxic vapors of SOx and Cl−. |
| Transport Information: | UN 2811 |
| PSA: | 45.31000 |
| LogP: | 2.60410 |
- 81281-59-67-Benzylideneaminotheophylline
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- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
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- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 114774-04-8
5-chloro-2-(α-methoxyimino)ethylthiophene
- 6310-09-4
2-acetyl-5-chlorothiophene
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 70℃; for 8h; | 96% |
| Conditions | Yield |
|---|---|
| With ytterbium(III) triflate In nitromethane at 20℃; for 4h; Friedel-Crafts acylation; | 90% |
| With zinc trifluoromethanesulfonate In nitromethane at 20℃; for 4h; Friedel-Crafts acylation; | 87% |
| With tetrachloromethane; aluminium trichloride | |
| With aluminium trichloride; Petroleum ether Behandeln des Reaktionsprodukts mit Wasser; | |
| Stage #1: acetyl chloride With aluminum (III) chloride In tetrachloromethane at 0℃; for 0.333333h; Friedel Crafts Acylation; Stage #2: 2-thienyl chloride In tetrachloromethane at 0℃; for 1.58333h; Friedel Crafts Acylation; Stage #3: With hydrogenchloride; water In tetrachloromethane |
| Conditions | Yield |
|---|---|
| With perchloric acid at 0 - 20℃; for 6.5h; | 81% |
| activated clay at 45 - 55℃; for 73h; | 52% |
| With phosphoric acid |
| Conditions | Yield |
|---|---|
| With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h; | A 69% B 7% |
| With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h; Product distribution; with different molar ratio; | A 47% B 22% |
| With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h; | A 47% B 22% |
- 96-43-5
2-thienyl chloride
- 108-24-7
acetic anhydride
- 109-63-7
trifluoroborane diethyl ether
A
- 6310-09-4
2-acetyl-5-chlorothiophene
- 6310-09-4
2-acetyl-5-chlorothiophene
| Conditions | Yield |
|---|---|
| sodium hydroxide at 25℃; Rate constant; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 81 percent / Na2CO3, AcOH / methanol; H2O / 2 h / Heating; pH 4.5 2: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating 3: 96 percent / 25percent HCl / 8 h / 70 °C View Scheme | |
| Multi-step reaction with 4 steps 1: 98 percent / NH2OH*HCl, Na2CO3, AcOH / methanol; H2O / 2 h / Heating 2: 95 percent / NaOH / dimethylformamide; H2O / 0.5 h / 10 °C 3: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating 4: 96 percent / 25percent HCl / 8 h / 70 °C View Scheme |
- 1956-45-2, 92313-45-6, 92313-54-7
2-acetylthiophene oxime
- 6310-09-4
2-acetyl-5-chlorothiophene
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 95 percent / NaOH / dimethylformamide; H2O / 0.5 h / 10 °C 2: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating 3: 96 percent / 25percent HCl / 8 h / 70 °C View Scheme |
- 114773-97-6
2-(α-methoxyimino)ethylthiophene
- 6310-09-4
2-acetyl-5-chlorothiophene
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating 2: 96 percent / 25percent HCl / 8 h / 70 °C View Scheme |
- 6310-09-4
2-acetyl-5-chlorothiophene
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
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Chemistry
IUPAC Name: 1-(5-Chlorothiophen-2-yl)ethanone
Synonyms： 1-(5-Chloro-2-thienyl)ethan-1-one ; 1-(5-Chloro-thiophen-2-yl)-ethanone ; 2-Acetyl-5-chlorthiophen ; 2-Chloro-5-acetylthiophene ; 5-Chlor-2-acetyl thiophen ; 5-Chlor-2-acetylthiophen ; 5-Chloro-2-acetyl thiophen
The Molecular Formula of 5-Chlor-2-acetyl thiophen (6310-09-4):C6H5ClOS
The Molecular Weight of 5-Chlor-2-acetyl thiophen (6310-09-4) :160.6213g/mol
The Molecular Structure of 5-Chlor-2-acetyl thiophen (6310-09-4):.gif){kind=small}
Index of Refraction: 1.559
Molar Refractivity: 39.56 cm3
Molar Volume: 122.3 cm3
Polarizability: 10-24cm3
Surface Tension: 41.9 dyne/cm
Density: 1.312 g/cm3
Flash Point: 108.3 °C
Enthalpy of Vaporization: 47 kJ/mol
Boiling Point: 233.3 °C at 760 mmHg
Vapour Pressure: 0.0562 mmHg at 25°C
Uses
5-Chlor-2-acetyl thiophen (6310-09-4) can be used in organic synthesis.
Safety Profile
Experimental reproductive effects. A flammable liquid. When heated to decomposition it emits toxic vapors of SOx and Cl−.
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes
WGK Germany: 3
Standards and Recommendations
DOT Classification: 3; Label: Flammable Liquid