1003845-06-4Relevant articles and documents
Development of a concise scaleable synthesis of 2-chloro-5-(pyridin-2-yl) pyrimidine via a Negishi cross-coupling
Perez-Balado, Carlos,Willemsens, Albert,Ormerod, Dominic,Aelterman, Wim,Mertens, Narda
, p. 237 - 240 (2007)
A practical and scaleable synthesis of 2-chloro-5-(pyridin-2-yl) pyrimidine, an intermediate in the synthesis of a selective PDE-V inhibitor, was developed. A Negishi cross-coupling between the in situ prepared 2-pyridylzinc chloride and 5-iodo-2-chloropyrimidine catalyzed by Pd(PPh3)4 afforded the product in one step. Development of a convenient purification did away with the necessity of chromatography, allowing the preparation of the product on kilogram scale.
Double Suzuki cross-coupling reaction of pyrimidine boronic acid: Synthesis of new versatile dielectrophile
Naseer, Muhammad Moazzam,Hameed, Shahid
experimental part, p. 330 - 334 (2012/08/08)
The double Suzuki cross-coupling reaction has successfully been applied for the synthesis of 5,5'-(5-butoxy-1,3-phenylene)bis(2-chloropyrimidine) with two reactive chloro groups and an alkoxy side chain starting from 2-chloropyrimidin-5-ylboronic acid and 1,3-dibromo-5-butoxybenzene. The reactivity of this dielectrophile was tested by reaction with aniline and phenol, a nitrogen and oxygen nucleophile, respectively. The new dielectrophile would further provide an ideal platform for the construction of large hetero-atom bridged macrocycles for desired properties and functions in supramolecular and material chemistry. Copyright
ORGANIC COMPOUNDS
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Page/Page column 67-68, (2009/05/28)
The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.