1012079-84-3

Basic information

• Product Name: 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester
• Synonyms: 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester
• CAS NO: 1012079-84-3
• Molecular Weight: 460.434
• Mol File: 1012079-84-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester(1012079-84-3)
• EPA Substance Registry System: 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester(1012079-84-3)

Safety Data

• Hazardous Substances Data: 1012079-84-3(Hazardous Substances Data)

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 342-23-4 bis(fluorophenyl)methanone 
• 393-52-2 2-Fluorobenzoyl chloride 
• 1026270-18-7 3,3-Bis-(2-fluoro-phenyl)-oxirane-2-carboxylic acid methyl ester 

Relevant articles and documents

Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists

A novel class of endothelin-A receptor ligands was discovered by high-throughput screening. Lead structure optimization led to highly potent antagonists which can be synthesized in a short sequence. The compounds are endothelin-A-selective, are orally available, and show a long duration of action.