342-23-4

Basic information

• Product Name: 2,2'-difluorobenzophenone
• Synonyms: 2,2'-difluorobenzophenone;Bis(2-fluorophenyl) ketone;bis(2-fluorophenyl)methanone
• CAS NO: 342-23-4
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.1988264
• EINECS: 206-439-6
• Mol File: 342-23-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 331.2°Cat760mmHg
• Flash Point: 127°C
• Appearance: /
• Density: 1.239g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2'-difluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-difluorobenzophenone(342-23-4)
• EPA Substance Registry System: 2,2'-difluorobenzophenone(342-23-4)

Safety Data

• Hazardous Substances Data: 342-23-4(Hazardous Substances Data)

Usage

General Description

2,2'-difluorobenzophenone, also known as benzophenone-1, is a benzophenone derivative with two fluorine atoms attached to the carbon atoms at the 2 position of the benzene rings. It is a yellow crystalline solid at room temperature and is insoluble in water. 2,2'-difluorobenzophenone is primarily used as a UV absorber in sunscreens and other cosmetic products to protect the skin and hair from damage caused by exposure to UV radiation. It functions by absorbing and dissipating UVB rays, thus preventing them from penetrating the skin and causing damage. It is also used as a photoinitiator in the manufacturing of polymers, coatings, adhesives, and inks. However, it has been found to have potential endocrine-disrupting properties, leading to concerns about its safety and environmental impact.

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 393-52-2 2-Fluorobenzoyl chloride 
• 501-53-1 benzyl chloroformate 
• 213128-18-8 benzyl (diphenylmethylene)carbamate 
• 119-61-9 benzophenone 
• 462-06-6 fluorobenzene 
• 201230-82-2 carbon monoxide 
• 1993-03-9 o-fluorophenylboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 126348-18-3 2,2'-difluorobenzilic acid 
• 261925-13-7 bis(2-fluorophenyl)methanol 

Downstream Products

• 1026270-18-7 3,3-Bis-(2-fluoro-phenyl)-oxirane-2-carboxylic acid methyl ester 
• 790658-80-9 bis(2-fluorophenyl)methanamine 
• 845821-92-3 2,2’-bis(diphenylphosphino)-benzophenone 
• 126348-20-7 diethyl 2-malonate 
• 126348-24-1 2-propane-1,3-diol 
• 1012079-84-3 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(2-fluoro-phenyl)-3-methoxy-propionic acid methyl ester 
• 126348-19-4 diethyl di(2-fluorophenyl)methylenemalonate 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

Unusual Fusion of α-Fluorinated Benzophenones under McMurry Reaction Conditions

By exposure of α-fluorinated benzophenones to McMurry reaction conditions, we have observed the remarkable formation of 9,10-diphenylanthracene derivatives. This unexpected transformation necessitates the cleavage of the exceptionally stable aromatic C?F bond under mild McMurry conditions. In this work, the condensation of several related fluorinated benzo- and acetophenones has been investigated, which allow us to propose a domino-like fusion mechanism for this unusual transformation. The scope and limitations of the fluorine-promoted benzophenone fusion are subsequently discussed.

Ligand-Free Palladium-Catalyzed Oxidative Carbonylative Homocoupling of Arylboron Reagents at Ambient Pressure

Arylboronic acids or potassium aryltrifluoroborates were readily oxidatively carbonylated to their corresponding diaryl ketones in high yields with high selectivities by ligand-free palladium-catalyzed homocoupling at atmospheric pressure. This novel method employs molecular oxygen or iodine as the oxidant and offers an attractive alternative to transition-metal-based oxidant systems.