10161-33-8 Usage
Description
Trenbolone, also known as trienolone or trienbolone, is a kind of anabolic androgenic steroid belonging to the 19-nortestosterone group. It can be supplied to veterinary medicine of livestock in order the boost muscle growth and appetite. It can also enhance the performance of athletes. It has several physiological effects: (1) enhance protein synthesis and nitrogen retention in the muscle tissues, which boost enhanced anabolism; (2) greatly promote insulin-like growth factor-1 (IGF-1) which is a highly effective anabolic hormone; (3) Greatly increase the red blood cell count to boost blood oxygenation which leads to improved muscular endurance; (4) Inhibit glucocorticoid hormones which inhibit the growth of muscle tissue and promote fat. (5) Improve food efficiency.
Chemical Properties
Yellow Solid
Originator
Parabolan,Negma,France,1980
Uses
Trenbolone is a controlled substance (anabolic steroid). It is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as [trenbolone acetate], trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.
Preparation
Trenbolone synthesis: To a cold mixture of 47.9 g 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in 375 mL anhydrous methylene chloride (DCM), a solution of 54.9 g compound (II-a) and 11.5 mL acetic acid in 150 mL anhydrous DCM is added dropwise under stirring, while keeping the internal temperature at -5 °C. The addition funnel is rinsed with 25 mL DCM and this aliquot is added to the reaction mixture. After 4 hours, reaction conversion reaches 99.25% by HPLC. The reaction mixture is quenched by addition of a solution composed of 5.7 g of Na2S2O5, 50 mL water and 10 mL MeOH. The obtained slurry is warmed to 15-23°C and left stirring for 0.5 h, after which it was filtered. The filter cake is washed with 2x40 mL DCM and the solid discarded. The obtained biphasic mixture is separated, and the organic phase washed twice with a solution of 100 mL water, 10 mL MeOH and 3.9 g of NaHCO3. The phases are separated, and the organic layer washed one final time with a solution of 100 mL water, 10 mL MeOH and 3.9 g of NaHCO3. The combined solution is concentrated with stirring to 150 mL (total volume) under vacuum, keeping the internal temperature below 30 °C. To the resulting solution, 150 mL of acetone are added, and the obtained mixture concentrated under vacuum to 150 mL (total volume) again, keeping the internal temperature below 30 °C. This addition/concentration protocol is repeated 3 times. The resulting suspension is cooled to 0 °C and kept at this temperature for 0.5 h with stirring, after which it is filtered, and the filter cake is washed twice with 50 mL cold acetone. The wet solid is dried at 40 °C under vacuum to give Trenbolone in 76% yield and 98.2 % A/A purity by HPLC.Synthesis of Trenbolone acetate
Definition
ChEBI: Trenbolone is a 3-oxo-Delta(4) steroid that is estra-4,9,11-triene carrying an oxo group at position 3 and a hydroxy group at position 17beta. It is a synthetic anabolic steroid used for muscle growth in livestock. It has a role as a plant metabolite and an endocrine disruptor. It is a 3-oxo-Delta(4) steroid, a 17beta-hydroxy steroid, a C18-steroid and an anabolic androgenic steroid.
Brand name
[Trenbolone is INN and BAN.
Therapeutic Function
Anabolic steroid
Side effects
Trenbolone's side effects aren't only physical but also mental, with users commonly reporting feeling increasingly: irritable, anxious, paranoid and depressed (than on other steroids).Such side effects can be linked to Trenbolone having a stimulating effect on the central nervous system, causing an increase in adrenaline output and thus shifting Tren-users into a state of fight or flight mode.
Safety Profile
When heated to
decomposition it emits acrid smoke and
irritating fumes.
References
https://en.wikipedia.org/wiki/Trenbolonehttps://www.steroid.com/Trenbolone.phpŠkorjanc, D, M. Brus, and I. Vojtic. "A short review of chain controlling systems in livestock production technology. " Agricultura (2005).
Check Digit Verification of cas no
The CAS Registry Mumber 10161-33-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10161-33:
(7*1)+(6*0)+(5*1)+(4*6)+(3*1)+(2*3)+(1*3)=48
48 % 10 = 8
So 10161-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1
10161-33-8Relevant articles and documents
NEW APPROACH TO SYNTHESIS OF TRENBOLONE
Pestovskii, S. N.,Ananchenko, S. N.,Rzheznikov, V. M.,Zaitseva, T. S.
, p. 263 - 264 (1988)
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Method for preparing pufferone acetate (by machine translation)
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Paragraph 0047-0054, (2019/11/21)
The invention discloses a method for preparing pufferone acetate, and belongs to the technical field of preparation and processing of hormone drugs. The process is carried out 3 - with ethylenedioxy estra-Δ. 5,10 , Δ9,11 -17-ketone is a starting raw material, and the preparation of the 3 botanerone acetate is carried out by 17 reducing the position of the ketone as an alcohol, hydrolyzing the position of the furanone, the 17 oxidative dehydrogenation, and the alcohol acetylation. The method has the advantages of cheap and easily available raw materials, simple reaction control, few byproducts, easy purification and high total yield, has extremely high competitiveness in production cost and operability, is suitable for industrial large-scale production and has good economic benefits. (by machine translation)